Kevin Plattner (Orcid ID: 0000-0002-2414-9593)

Zahra Gharailoo (Orcid ID: )

Simon Zinkhan (Orcid ID: )

Paul Engeroff (Orcid ID: 0000-0002-3409-512X)

Martin Bachmann (Orcid ID: 0000-0003-4370-2099)

Monique Vogel (Orcid ID: 0000-0002-5219-4033)

Title: IgE glycans promote IgG anti-IgE autoantibodies that facilitate IgE serum clearance via CD23

Authors: Kevin Plattner¹, Zahra Gharailoo¹, Simon Zinkhan¹, Paul Engeroff, Martin F. Bachmann^1,2 and Monique Vogel¹*

¹Department of Biomedical Research Bern (DBMR), University Hospital for Rheumatology, Immunology, and Allergology, University of Bern, Bern, Switzerland.

²Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, UK.

*Correspondence to monique.vogel@dbmr.unibe.ch

Competing interests: M. F. Bachmann is a shareholder and board member of Saiba and Saiba animal health AG. All other authors declare no conflict of interest.

Author Contributions: K.P. designed, performed and interpreted experiments. Z.G. and S.Z helped performing experiments. M.F.B., and M.V. supervised, designed and interpreted experiments. K.P. and M.V. wrote the manuscript.

Funding: This project was supported by funding from the following grants: SNF grant 310030_179165/1 to PD Dr. Monique Vogel; SNF grant 310039_185114 to Martin F. Bachmann