All data included in this study are available upon request by contact with the corresponding author.

Conflicts of interest

The authors declare no conflict of interest with regard to the publication of this paper.

There are no funders to report for this submission.

Author contributions：

Yanping Jiang performed experiment and the data analyses, and wrote the manuscript;

Lu Wang performed the experiment and wrote the manuscript;

Yanping Jiang and Lu Wang contributed equally to this work and should be considered co-first authors.

Yaqin Peng contributed significantly to analysis and manuscript preparation;

Jian Qin contributed to the conception of the study

Aili Tan helped perform the analysis with constructive discussions.

Shujun Wang helped perform data analyses