Figures and Tables
Table 1. Baseline characteristics of patients. AH adenoid hypertrophy, AR allergic rhinitis, * Chi-square, ** Mann Whitney U test.
Figure 1. Novel classification system of adenoids based on appearance. (A) Edematous-type adenoids. (A’) Edematous type, the tissue structure was loose, had edema, was accompanied by dilation and congestion of small vessels. (B) Common-type adenoids. (B’) Common type, the whole structure was consistent with that of lymphoid tissue. (C) Fibrous-type adenoids. (C’) Fibrous type, the dense fibrous connective tissue hyperplasia between lymphoid tissues. Among the 44 cases of AH without AR, 42 (95.45%) of adenoids were found to be the common type (D). Among the 106 cases of AH with AR, 72 (67.92%) of adenoids were found to be of the edematous type (E).
Figure 2 : The morphology and age of adenoids after surgical treatment. (A) Of the 101 cases of adenoid tissue, 30 (30%) were the edematous type, 57 (56.44%) were the common type, and 13 (13%) were the fibrous type. (B) The age of edematous type was 59.77 ± 4.052, common type was 64.26 ± 3.366, and fibrous type was 81.77 ± 7.122. There was a significant difference in the age between edematous type and fibrous type (*P < 0.05).
Figure 3 : Expression of leukotriene receptors and glucocorticoid receptors in the adenoid tissues of different types. (A) Immunohistochemical staining showed that the edematous type had a higher eosinophil count with larger nuclei and red cytoplasm than the common type and fibrous type. CysLTR1 was expressed in brown granules in all three types of adenoid tissues. CGR-α and CGR-β were highly expressed in the edematous type, with a lower expression in the common type and fibrous type. (B) Western blot showed that CysLTR1 and CysLTR2 were expressed in all three types of adenoid tissues, and the difference in expression was not statistically significant. CGR-α was mainly expressed in the edematous type, which was significantly different from that in common type and fibrous type.
Figure 4 : The relationship between eosinophil count in the adenoid tissue and blood and allergic history. (A) The eosinophil count in the edematous type was higher than that in the common type (P< 0.01). (B) There was a positive correlation between the eosinophil count in the adenoid tissue and in the blood (r2 = 0.1023, P < 0.01). (C) There was no significant difference in the number of eosinophils in the adenoid tissue and the history of allergic disease.