Figure
3: Representative A) H&E and B) trichrome images of capsular tissue-Images show envelope resorption and capsule thickening over 2, 13 and 26
weeks in the presence of the ECM envelope. Images from pockets receiving
CIEDs without envelopes showed similar connective tissue formation at 13
and 26 weeks.
Histology sections were also scored for neovascularization on a 0 to 4
point scale by an independent blinded pathologist (Table 1) .
The CanGaroo ECM Envelope group had a significantly higher
neovascularization average score of 2.1 compared to a mean of 1.7 in the
CIED without envelope group (p<.05, Student’s t-test) .
In either group, no significant mineralization was observed in the
tissue. No necrotic tissue areas were observed, and only low levels of
apoptotic cells normally seen in surgical sites were found.