2.3 Clinical efficacy indicators
The two main endpoint evaluation indicators were the stability of
hemoglobin levels, which was defined as the maintenance of hemoglobin
levels above 60 g/l without blood transfusion within 4 to 8 weeks after
chemotherapy), and the change in lactate dehydrogenase level from
baseline to 12 weeks (fold increase compared with the normal value).
Other prespecified measurements included the proportion of
reticulocytes, total bilirubin level, proportion of PNH clone cells and
dosage of corticosteroids after chemotherapy during treatment.