Epitope Screening Using Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS): An Optimized Workflow for Accelerated Evaluation of Lead Monoclonal Antibodies
Shaolong Zhu1, Peter Liuni2, Tricia Chen1, Camille Houy1, Derek J. Wilson2, D. Andrew James1,2*
1Analytical Sciences, Sanofi Pasteur Ltd, Toronto, Ontario, M2R 3T4, Canada
2Centre for Research in Mass Spectrometry, Department of Chemistry, York University, Toronto, Ontario, M3J 1P3, Canada
Keywords: Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS), epitope screening, monoclonal antibody, Pertactin, vaccine
Corresponding Author
* D. Andrew James, PhD
Sanofi Pasteur Limited
1755 Steeles Ave. W., Toronto M2R 3T4, Canada
Telephone: +1-416-667-2100
Email: Andrew.James@sanofi.com
Abbreviation: HDX-MS, Hydrogen Deuterium Exchange – Mass Spectrometry; mAb, monoclonal antibody; PRN, Pertactin.