Abbreviations:
16HBE14o- cells - an SV40-transformed human bronchial epithelial cell
line
2at-LIGRL-NH2 -
2-aminothiazole-LIGR-NH2, a PAR2 agonist
2f-LIGRLO-NH2 - 2-furoyl-LIGRLO-NH2, a
PAR2 agonist
AEBSF - 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride, a serine
proteinase inhibitor
AC-55541 - PAR2 antagonist
AC-264613 - PAR2 antagonist
AZ8838 - PAR2 antagonist
AZ3451 - PAR2 antagonist
BRET - bioluminescence resonance energy transfer
C391 - compound 391, a PAR2 antagonist
[Ca2+]i - Intracellular
Ca2+ concentration
CPMCRI - California Pacific Medical Center Research Institute
E64 -
(1S ,2S )-2-(((S )-1-((4-Guanidinobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)cyclopropanecarboxylic
acid, a cysteine proteinase inhibitor
GB88 - PAR2 antagonist
H&E - haematoxylin and eosin stain
HEK 293 - human embryonic kidney cell line
ICW - In Cell Western
K-14585 - PAR2 antagonist
LHC - Lechner and LaVeck basal medium
Luc - Luciferase
MAPK - mitogen activated protein kinase
Max Rrs - maximum total airway resistance
MCS - Matrix coating solution
MEM - Minimal essential medium
p-MAPK - phosphorylated MAPK
PAR2 - proteinase-activated receptor-2
PAS - Periodic Acid Schiff
PAR2-/-- PAR2 knockout animals
YFP - Yellow fluorescent protein