Title: Novel proteinase-activated receptor-2 (PAR2) antagonist C391 inhibits Alternaria -induced human airway epithelial signaling and asthma indicators in murine models
Running Title: Inhibition of PAR2 signaling in allergen-induced asthma
Authors: Candy M. Rivas1,2, Michael C. Yee3, Kenneth J. Addison2,4, Marissa Lovett1, Kasturi Pal3, Julie G. Ledford2,4, Gregory Dussor5, Theodore J. Price5, Josef Vagner6, Kathryn A. DeFea3,7 and Scott Boitano*1,2,4,6, 8
1University of Arizona Physiological Sciences Graduate Interdisciplinary Program
2University of Arizona Heath Sciences, Asthma and Airway Disease Research Center
3University of California Riverside, Biomedical Sciences
4University of Arizona Heath Sciences, Department of Cellular and Molecular Medicine
5University of Texas at Dallas, School of Behavioral and Brain Sciences and Center for Advanced Pain Studies
6University of Arizona Bio5 Collaborative Research Institute
7PARMedics, Inc.
8University of Arizona Heath Sciences, Department of Physiology
*Corresponding Author : Kathryn A. DeFea, Ph.D.; CEO, PARMedics Inc.; 41593 Winchester Rd. Suite 228, Temecula, CA, 92590 and Professor Emeritus, Biomedical Sciences, University of California Riverside; Riverside, CA, 92521 kdefea@parmedics.com, +1-925-967-2363
Author Contributions: CMR: experimental design, experiments, manuscript writing and editing; MCY: conducted experiments and data analysis, manuscript editing; KJA: experiments and data analysis; ML: conducted experiments and data analysis; KP: conducted experiments and data analysis; JGL; experimental design, manuscript editing; GD: experimental design, manuscript editing; TJP: experimental design, data analysis, manuscript writing and editing; JV: experimental design, data analysis and manuscript editing; KAD: experimental design, data analysis, manuscript writing and editing; SB: experimental design, experiments, data analysis, manuscript writing, and editing
Word Count : 6187
Acknowledgements : We would like to thank Dr. Kim Barrett for her guidance in helping to prepare the manuscript. This work was funded in part through grants from the National Institute of Health grants (NINDS NS098826 SB, TJP, JV, GD; NIAID AI140257 SB). CMR was an American Physiological Society William H. Townsend Porter Pre-doctoral Fellow.
Competing Interests : There are no competing interests.