Figure 4. Overview of relationships between modelled promoters and fish species lifespan. A. Mean weighting for each promoter in the lifespan prediction model ordered by magnitude and directionality (large negative to large positive). Bars are coloured by the Pearson correlation coefficient between known lifespan and observed over expected ratio (CpG O/E) for each promoter. Only every tenth promoter is labelled on this x axis (total n = 932). B. Pearson correlation coefficients for each promoter compared to mean weighting in the lifespan model. C. Mean CpG O/E for each promoter compared to mean weighting in the lifespan model. Colours indicate if both the correlation and model weighting were negative, positive, or varied between the two as per the legend. Transparent bars and points indicate that the Pearson correlation between promoter CpG O/E and lifespan was not significant.
Figure . Functional enrichment analysis showing biological functions and pathways over-represented in the fish lifespan model promoter associated genes for: A. promoters positively weighted in the model and B. promoters negatively weighted in the model. HP indicates functions derived from the Human Protein Atlas, and REAC from the Reactome database. A table of these results can be found in Table S7.