Figure 4. Overview of
relationships between modelled promoters and fish species lifespan. A.
Mean weighting for each promoter in the lifespan prediction model
ordered by magnitude and directionality (large negative to large
positive). Bars are coloured by the Pearson correlation coefficient
between known lifespan and observed over expected ratio (CpG O/E) for
each promoter. Only every tenth promoter is labelled on this x axis
(total n = 932). B. Pearson correlation coefficients for each promoter
compared to mean weighting in the lifespan model. C. Mean CpG O/E for
each promoter compared to mean weighting in the lifespan model. Colours
indicate if both the correlation and model weighting were negative,
positive, or varied between the two as per the legend. Transparent bars
and points indicate that the Pearson correlation between promoter CpG
O/E and lifespan was not significant.
Figure . Functional enrichment
analysis showing biological functions and pathways over-represented in
the fish lifespan model promoter associated genes for: A. promoters
positively weighted in the model and B. promoters negatively weighted in
the model. HP indicates functions derived from the Human Protein Atlas,
and REAC from the Reactome database. A table of these results can be
found in Table S7.