Data collection
Data collection was done by using the disease-specific questionnaires of
the EPA-HAE instrument13. The questionnaires were
based on a recent (6 month) experience of the patients with prodromes
and attacks. Personal interviews were performed by the principal
investigator (ILN). In describing their experience, patients were
directed to recount the dimensions of prodromes and attacks (i.e. pain,
severity, limitation, functionality) in each affected body cluster
(domain). The average time for answering the quesionnaires was
approximately 30 minutes.