Data collection
Data collection was done by using the disease-specific questionnaires of the EPA-HAE instrument13. The questionnaires were based on a recent (6 month) experience of the patients with prodromes and attacks. Personal interviews were performed by the principal investigator (ILN). In describing their experience, patients were directed to recount the dimensions of prodromes and attacks (i.e. pain, severity, limitation, functionality) in each affected body cluster (domain). The average time for answering the quesionnaires was approximately 30 minutes.