Limitations of the study
The study was performed in a single country, with its unique cultural
and linguistic charchteristics. Patients who consented to participate
represent only 33.5% of the total studied HAE patients.20 Additionally, patient reports are mostly subjective
and diverge considerably depending on each patient’s experience. Despite
being based on a recent (6 month) experience with prodromes and attacks,
the retrospective design may involve recall bias, which we hope to
address by a prospective study, in which at least several consequtive
prodromes and attacks will be reported.