Limitations of the study
The study was performed in a single country, with its unique cultural and linguistic charchteristics. Patients who consented to participate represent only 33.5% of the total studied HAE patients.20 Additionally, patient reports are mostly subjective and diverge considerably depending on each patient’s experience. Despite being based on a recent (6 month) experience with prodromes and attacks, the retrospective design may involve recall bias, which we hope to address by a prospective study, in which at least several consequtive prodromes and attacks will be reported.