Evaluating prodrome dimensions
Patients were asked to rate their experience with prodromes in different dimensions measured on a Likert scale (Visual Analog Scale, VAS) of 0 to 10cm. Analysis of variance (ANOVA) demonstrated a significant and consistent difference between dimensions of prodromes in various locations (clusters). Paired t-test showed significant differences between the dimensions of prodromes and attacks across all clusters (Figure 2). Generally, the severity of prodromes in the abdomen and the extremities exceeded the other clusters (urogenital, facial, oropharyngeal). It should be noted that mean severity of prodromes was much less (by half) as compared to attacks across all dimensions (pain, severity and functionality) in all the pre-specified domains (clusters) (Figure 2).