Conclusion:
In conclusion, the differential diagnosis in a patient with hoarseness, dyspnea, and subglottic mass must consist of neuroendocrine carcinomas. Due to tumor rarity, pathological diagnosis should be confirmed by immonohistochemistery. Irradiation and chemotherapy are recommended for treatments in poorly differentiated NEC.This case report of poor differentiated NEC and the corresponding literature review provide useful insight for otolaryngologist to improve their knowledge in the diagnosis and treatment of this aggressive neoplasm.