Prognosis
 \citet{Ricketts2022} evaluated childhood predictors of adult tic severity and impairment and found that childhood severity of tics and female sex are important predictors for tic severity and impairment in adulthood. 
Using an online survey, 351 adult males with TS fulfilled questionnaires about adverse childhood experiences (ACEs) and lifetime version of the Yale Global Tic Severity Scale \cite{Yang2022}. An association between ACEs and higher lifetime tic severity and impairment was found. TS genetic risk might moderate the association between ACE score and tic impairment.

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