For the first time, a study explored the relationship between the microlesion effect and the anatomic location of implanted DBS leads in the CM nucleus of the thalamus \citep{Morishita2023}. The microlesion effect refers to the immediate improvement of symptoms after lead implantation and is considered to result from edema, microhemorrhage, and/or the disruption of fibers along the trajectory of the electrodes. All 6 patients with TS included in this study experienced tic improvement related to microlesion effect. Connectivity analyses showed connections between the area related with microlesion effect and the prefrontal cortices and globus pallidus.