Previous research has indicated that dysfunction of striatal dopamine plays a significant role in motor tics in GTS. Rusheen et al. investigated the effect of centromedian (CM) thalamic DBS on modulating dopamine activity in the dorsomedial striatum, using a comprehensive approach combining electrophysiology, electrochemistry, optogenetics and behavioural measurements \cite{Rusheen_2023}. They found that CM DBS evoked synaptic dopamine release and elevated tonic dopamine levels via striatal cholinergic interneurons. Conversely, inactivation of D2 receptors reduced clinical response. This pivotal study suggests that tic improvement with thalamic DBS is mediated by D2 receptor activation, providing further evidence of the involvement of dopamine dysfunction as a crucial factor for motor tics in GTS.