Author contribution
GCT conducted the experiments, performed the statistical analysis, wrote, and edited the original draft. ANC and YTT participated in experiments. OK and SC reviewed the manuscript. Study concept and design: YTT, EY, NA, DS, GE, OD, MAK, BM, GA, FT, FC, OE, KM, OK, SC. All authors contributed to and have approved the final version of the manuscript.