ABSTRACT
Background: Left
ventricular non compaction (LVNC) is a structural abnormality of the
left ventricular myocardium of unknown cause. Cardiovascular system
involvement is an important manifestation, in juvenile systemic lupus
erythematosus (jSLE), considered as a leading cause of morbidity and
mortality. Pericardium, myocardium, endocardium, heart valves, coronary
vessels, and cardiac autonomic functions may be affected in jSLE
patients. LVNC occurs in isolation or associated with neuromuscular
disorders (NMDs). However, its association with jSLE was rarely
described.
Herein, We aimed to present a case of a jSLE patient with LVNC.Case presentation: According to the SLICC 2012 criteria, a
15-year-old girl was diagnosed with jSLE with a past history of
Hashimoto’s thyroiditis presented with paroxysmal chest pain, exertional
dyspnea, headache, and polyarthralgia. Clinical examination revealed a
febrile patient. There was no polypnea, no evidence of right heart
failure, no audible murmur on cardiac auscultation, and no edema of the
lower limbs. The biological analysis revealed a Leucopenia, anemia,
elevated erythrocyte sedimentation rate and C-reactive protein. The
immunological test revealed homogeneous antinuclear antibodies at 1/10
000 with the positivity of both anti-native DNA and anti-SSA antibodies.
The electrocardiogram showed sinus tachycardia and a cardiac magnetic
resonance imaging (CMRI) was performed confirming the non-compaction of
the LV with an hypertrabeculated sub-endocardium. The patient received
high-dose corticosteroids associated with beta-blocker therapy with a
favorable outcome. Conclusion: We reported one of the rare,
documented cases of a girl with LVNC associated jSLE with a past history
of Hashimoto’s thyroiditis. Thus, the association between
jSLE, and LVNC should be considered, and requires
further research in order to find the probable mechanism joining both
entities.