Figure and table legends
Table 1 Baseline information of participants, a Anova Analysis. b.Chi-square test. c.Kruskal-wallis analysis.
Figure 1 The reduction in symptom score: (A) The reduction in VAS score 2 weeks after ESS. (B)The reduction in VAS score 1 month after ESS. (C) The reduction in VAS score 6 months after ESS. (D)The reduction in VAS score 1 year after ESS. (E) The reduction in SNOT-22 score 2 weeks after ESS. (F)The reduction in SNOT-22 score 1 month after ESS. (G)The reduction in SNOT-22 score 6 months after ESS. (H)The reduction in SNOT-22 score 1 year after ESS. (I) The reduction in L-K score 2 weeks after ESS. (J)The reduction in L-K score 1 month after ESS. (K)The reduction in L-K score 6 months after ESS. (L) The reduction in L-K score 1 year after ESS. ESS, endoscopic sinus surgery.
Figure 2 Endoscopic photographs from one patient for each of the three groups. Figure(A,F,K)show the preoperative endoscopic condition of nasal cavity. Figure(B,G,L) show the postoperative ethmoid sinus cavity 2 weeks after ESS. Figure(C,H,M) show the postoperative ethmoid sinus cavity 1 month after ESS. Figure(D,I,N) show the postoperative ethmoid sinus cavity 6 months after ESS. Figure(E,J,O) show the postoperative ethmoid sinus cavity 1 year after ESS. ESS, endoscopic sinus surgery.
Figure 3 SEM photographs from one patient for each of the three groups. Figure(A,D,G)show the preoperative nasal mucosa. Figure(B,E,H) show the postoperative nasal mucosa 2 weeks after ESS. Figure(C,F,I) show the postoperative nasal mucosa 1 month after ESS. SEM, scanning electron microscope. ESS, endoscopic sinus surgery.
Figure 4 The mRNA expression of CP110, Foxj1 and Tap73. (A) The CP110 mRNA expression among control group, rh-bFGF nasal-spray and nasal-drop group before ESS. (B) The CP110 mRNA expression among the three groups 2 weeks after ESS. (C) The CP110 mRNA expression among the three groups 1 month after ESS. (D) The Foxj1 mRNA expression among the three groups before ESS.(E) The Foxj1 mRNA expression among the three groups 2 weeks after ESS.(F) The Foxj1 mRNA expression among the three groups 1 month after ESS. (G) The Tap73 mRNA expression among the three groups before ESS. (H)The Tap73 mRNA expression among the three groups 2 weeks after ESS. (I) The Tap73 mRNA expression among the three groups 1 month after ESS.
Figure 5 The reduction in VAS score, SNOT-22 and L-K score in eCRS of the three group. (a) The reduction in VAS score 2 weeks after ESS. (B)The reduction in VAS score 1 month after ESS. (C)The reduction in VAS score 1 month after ESS. (D)The reduction in VAS score 1 month after ESS.(E) The reduction in SNOT-22 score 2 weeks after ESS. (F)The reduction in SNOT-22 score 1 month after ESS. (G)The reduction in SNOT-22 score 6 months after ESS. (H)The reduction in SNOT-22 score 1 year after ESS. (I)The reduction in L-K score 2 weeks after ESS. (J) The reduction in L-K score 1 month after ESS. (K)The reduction in L-K score 6 months after ESS. (L)The reduction in L-K score 1 year after ESS. eCRS, eosinophil chronic rihnosinusitis. ESS, endoscopic sinus surgery.
Figure S1 Consort Flow Diagram: Flow diagram of participants enrolled in this study. Conventional treatment(antibiotics for 3 days and nasal corticosteriod and irrigation for 1 month).
Figure S2 The reduction of symptom score (A) The reduction in obstruction score 2 weeks after ESS. (B)The reduction in obstruction score 1 month after ESS. (C)The reduction in obstruction score 6 months after ESS. (D)The reduction in obstruction score 1 year after ESS. (E)The reduction in rhinorrhea score 2 weeks after ESS. (F)The reduction in rhinorrhea score 1 month after ESS. (G)The reduction in rhinorrhea score 6 months after ESS. (H)The reduction in rhinorrhea score 1 year after ESS.
(I)The reduction in olfactory score 2 weeks after ESS. (J)The reduction in olfactory score 1 month after ESS. (K) The reduction in olfactory score 6 months after ESS. (L)The reduction in olfactory score 1 year after ESS. (M) The reduction in facial pressure score 2 weeks after ESS. (N)The reduction in facial pressure score 1 month after ESS. (O)The reduction in facial pressure score 6 months after ESS.(P)The reduction in facial pressure score 1 year after ESS. (Q)The reduction in headache score 2 weeks after ESS. (R)The reduction in headache score 1 month after ESS. (S)The reduction in headache score 6 months after ESS. (T)The reduction in headache score 1 year after ESS. ESS, endoscopic sinus surgery. ESS, endoscopic sinus surgery.
Figure S3 The reduction in VAS score, SNOT-22 and L-K score in non-eCRS of the three group. (a) The reduction in VAS score 2 weeks after ESS. (B)The reduction in VAS score 1 month after ESS. (C)The reduction in VAS score 1 month after ESS. (D)The reduction in VAS score 1 month after ESS.(E) The reduction in SNOT-22 score 2 weeks after ESS. (F)The reduction in SNOT-22 score 1 month after ESS. (G)The reduction in SNOT-22 score 6 months after ESS. (H)The reduction in SNOT-22 score 1 year after ESS. (I)The reduction in L-K score 2 weeks after ESS. (J) The reduction in L-K score 1 month after ESS. (K)The reduction in L-K score 6 months after ESS. (L)The reduction in L-K score 1 year after ESS. eCRS, eosinophil chronic rihnosinusitis. ESS, endoscopic sinus surgery.