Ciliogenesis-associated markers
To further verify the effect of rh-bFGF on the cilia growth, the mRNA expression of CP110, Tap73 and Foxj1 was detected. The expression of CP110, Tap73 and Foxj1 in three groups before ESS was on the same level(Figure4A,D,G). The expression of CP110 and Tap73 of the rh-bFGF experimental groups was significantly lower than that of control group after ESS while no statistic difference was found between nasal-spray group and control group at 2 weeks(Figure4B,C,H,I). The expression of Foxj1 of the rh-bFGF experimental groups was significantly lower than that of control group after ESS. However, there was no difference between nasal-spray group and control group at 1 month(Figure4E,F).