STUDY POPULATION INTERVENTION OUTCOMES RISK OF BIAS
Westermann 2016
77 women undergoing vaginal hysterectomy with prolapse repairs
Intervention cotton gauze (2”*15’), that was tightly packed into the vagina at the completion of the surgical procedure Control no packing Co-intervention(s) all women received controlled analgesia for breakthrough pain as required and had indwelling transurethral catheters overnight Primary · Pain (vas 0 (no pain) to 100 (severe pain)) Secondary · Satisfaction after surgery (vas 0 (no satisfied) to 100 (very satisfied)) · Bother attributable to the vaginal packing (vas 0 (not bothersome) to 100 (very bothersome)) · Postoperative vaginal blood loss Randomization Low risk (sequential number randomization concealed by sealed, opaque envelopes) Blinding Low risk (participants and outcome assessors were blinded to the intervention, all women responded to vas assessments) Follow up, Complete Other, n/a Overall, low risk
Thiagamoorthy 2013
173 women undergoing vaginal hysterectomy with prolapse repairs
Intervention cotton gauze (7.5 m*10 cm) soaked in proflavine antiseptic solution, that was tightly packed into the vagina at the completion of the surgical procedure Control no packing Co-intervention(s) all women had an indwelling Foley catheter until the following morning and received analgesia for breakthrough pain Surgeons could decide to place a pack at discretion regardless of the randomization Primary · Pain (short-form McGill Pain Questionnaire) Secondary · Infective and haematological postoperative morbidity Randomization Low risk (randomization concealed by sealed envelopes) Blinding Low risk (participants and outcome assessors were blinded to the intervention, responded questionnaires before packing removal) Follow up, Complete Other, n/a Overall, low risk
Urzua 2013
144 women undergoing vaginal hysterectomy
Intervention gauze soaked in povidone iodine for 24 h. Control no packing Co-intervention(s) all women received antibiotic prophylaxis (cefazolin, 1 g i.v.), had an indwelling Foley catheter for 24 h and received analgesia for breakthrough pain Primary · Postoperative vaginal blood loss Secondary · Pain (vas 0 (no pain) to 10 (severe pain)) · Postoperative complications (DINDO II or higher) Randomization Unclear (described as randomized) Blinding Unclear (blinded outcome assessment reported) Follow up, Unclear Other trial reported as conference abstract Overall unclear risk
Baumgarten 2010
43 women undergoing vaginal surgery
Intervention vaginal packing Control no packing Co-intervention(s) not described · Postoperative complications (bleeding or infection) The trial report did not discriminate primary or secondary outcomes Randomization Unclear (described as randomized) Blinding High (described as open trial) Follow up, Unclear Other, trial reported as conference abstract Overall, unclear risk