Abstract
Objectives:The purpose of this study was to improve the diagnostic rate by analyzing the data of the clinical, radiology and pathological of Allergic fungal rhinosinusitis (AFRS).
Method: The data of patients with chronic sinusitis (CRS) treated in our center from January 2015 to December 2020 were analyzed. The discharged patients diagnosed with AFRS and the suspected cases in the description of radiology or surgical records were reviewed, combined with specific immunoglobulin E (IgE) examination, they were divided into three groups: AFRS, suspected AFRS and fungal ball sinusitis (FBS). The participants’ demographic, laboratory data and clinical characteristics were all analyzed.
Results: 631 patients with non-invasive fungal sinusitis were treated in the past 6 years. 29 cases of AFRS, 69 cases of suspected AFRS and 533 cases of FBS. A total of 98 confirmed and suspected AFRS cases were identified, with an average age of 34.3 years, 25 cases with bone erosion. The significant differences were observed in age, eosinophils or basophils percentage, total serum IgE, CT Lund-Mackay score, combined with allergic rhinitis, asthma and hypoolfactory between AFRS or confirmed AFRS and FBS, but no differences between AFRS and suspected AFRS.
Conclusion: AFRS may be misdiagnosed due to the low detection of fungi. In order to reduce the recurrence of the disease, we can consider the diagnosis of AFRS for patients with clinical, radiology and immunological characteristics consistent with AFRS but without fungal etiology.