Conclusions
SEGUL is an ultrafast, memory-efficient tool to manipulate alignments and generate summary statistics for phylogenomics. It is consistently fast with low memory usages regardless of dataset, operating system, and CPU architecture, while providing extra features, such as a log file, a more informative terminal output, GUI application, and a broad array of summary statistics. SEGUL support devices from smartphones, tablets, laptops, and desktops, to high-performance computers. Their efficient use of computing resources, cross-platform support, and the inclusion of a log file offers greater repeatability and accessibility than alternative applications.