Figure Legends
Figure 1: Asthma prevalence and ICU admission for hospitalized COVID-19 patients. (a) Prevalence of asthma in hospitalized COVID-19 patients. The y-axis denotes the prevalence of the precondition asthma in hospitalized COVID-19 patients in percent. The filled bars correspond the prevalences of the precondition asthma in hospitalized COVID-19 patients in Germany (Frankfurt, Gießen and Marburg; yellow), Moscow (orange), and Stanford (purple). The open bars indicate the prevalence of asthma in the general population in the corresponding areas. The vertical lines indicate the 95% Clopper-Pearson confidence interval.
(b) Odds ratios for asthma and ICU admission. The x-axis denotes the odds ratio between Odds (ICU|asthma) and Odds (ICU|no asthma). Dots indicate the value of the point-estimate for Germany (Frankfurt, Gießen and Marburg; yellow), Moscow (orange), and Stanford (purple). The horizontal lines indicate the 95% confidence interval. The dotted vertical line denotes an odds ratio of 1, i.e., no association.
Figure 2: Additional preconditions for hospitalized COVID-19 patients with or without asthma. (a) Prevalences of additional preconditions in patients with and without asthma. The y-axes denote the prevalences of the respective precondition. The filled bars correspond the prevalences of the respective precondition among hospitalized COVID-19 patients with asthma in Germany (Frankfurt, Gießen and Marburg; yellow), Moscow (orange), and Stanford (purple). The striped bars denote the prevalences of the respective precondition among hospitalized COVID-19 patients without asthma. The horizontal line indicates significant differences in the prevalences of the respective precondition between patients with asthma and without asthma. COPD: Chronic Obstructive Pulmonary Disease. (b) Frequency of patients with 0 to 11 additional preconditions (except asthma). The x-axis denotes the number of additional preconditions per patient. The y-axis denotes the frequency of patients in percent.
Figure 3: Confounder analysis. Odds of being asthmatic given that the patient was from Stanford is shown on the left (no adjustment) for the indicated age groups. The odds of being asthmatic given that the patient was from Stanford, female and had no comorbidity is shown on the right (adjusted) for the indicated age groups. The vertical lines indicate the 95% confidence interval. The red horizontal line indicates the Odds of asthma in the general population.
Figure 4: Peripheral blood eosinopenia for hospitalized COVID-19 patients with or without asthma . Average eosinophil counts at admission (Ad), during the hospital stay (Du), and at discharge (Di) for patients with asthma (solid bars) and without asthma (striped bars). The y-axis denotes the eosinophil count time s103 per μl. The vertical lines denote the 95% confidence interval. The numbers below the bars indicate the number of patients.
Supplementary Figure 2: Laboratory parameters for hospitalized COVID-19 patients with or without asthma. Average laboratory parameters at admission (Ad), during the hospital stay (Du), and at discharge (Di) for patients with asthma (solid bars) and without asthma (striped bars). The y-axis denotes the value with the indicated unit. The vertical lines denote the 95% confidence interval. The numbers below the bars indicate the number of patients.