Systematic Literature Search
Five
electronic databases (PubMed/MEDLINE, EMBASE[Ovid], Scopus, Cochrane
Library, and Web of Science) were
searched from inception through
April 28th,2022. Literatures searched from the Chinese Clinical Trials
Registry and ClinicalTrials.gov were classified as
literature from other sources. A
Population, Intervention, Comparison, Outcome, and Study (PICOS) design
strategy was adopted. The target population of the study was patients
with recurrent respiratory papillomatosis. The intervention was surgery
with microdebrider or CO2 laser or KTP laser. The effectiveness of the
procedural setting was based on these primary outcomes of interest:
intraoperative and postoperative complications, and complication rate. A
comprehensive search strategy using PubMed’s MeSH and EMBASE’s EMTREE
subject headings and keywords consisting of three main concepts was
developed: recurrent respiratory papillomatosis, treatment modality or
surgical technique applied or instruments used in the surgical
procedures (Appendix, Table 1). The search was limited to humans only.
The strategy was designed for ease in replication across databases, and
it was adapted as needed for additional searches across the table of
contents searches and unique features in Ovid databases.