Systematic Literature Search
Five electronic databases (PubMed/MEDLINE, EMBASE[Ovid], Scopus, Cochrane Library, and Web of Science) were searched from inception through April 28th,2022. Literatures searched from the Chinese Clinical Trials Registry and ClinicalTrials.gov were classified as literature from other sources. A Population, Intervention, Comparison, Outcome, and Study (PICOS) design strategy was adopted. The target population of the study was patients with recurrent respiratory papillomatosis. The intervention was surgery with microdebrider or CO2 laser or KTP laser. The effectiveness of the procedural setting was based on these primary outcomes of interest: intraoperative and postoperative complications, and complication rate. A comprehensive search strategy using PubMed’s MeSH and EMBASE’s EMTREE subject headings and keywords consisting of three main concepts was developed: recurrent respiratory papillomatosis, treatment modality or surgical technique applied or instruments used in the surgical procedures (Appendix, Table 1). The search was limited to humans only. The strategy was designed for ease in replication across databases, and it was adapted as needed for additional searches across the table of contents searches and unique features in Ovid databases.