Post-operative assessment:
After one week of surgery, patients were divided into two groups by a
closed envelope technique of randomization, but no blinding was
involved. The Itraconazole group was given oral Itraconazole 400 mg once
daily for six weeks. The Methylprednisolone group was given tapering
doses of 16mg, 8mg, and 4mg of Methylprednisolone, each taken for two
weeks. Both groups were given topical fluticasone nasal spray, one puff
(50mcg) each nostril once daily and saline nasal douching for six weeks.
The Itraconazole group had a baseline liver function test repeated every
two weeks. In case of alteration of values, the drug was withdrawn.
Similarly, in the Methylprednisolone group, baseline blood sugar levels
(Fasting Blood Sugar [FBS], Post Prandial Blood Sugar [PPBS],
and Glycosylated Hemoglobin [HbA1c]) were checked. People with
diabetes receiving Methylprednisolone were monitored every two weeks. In
case of poor glycemic control, the drug was withdrawn. At the end of 6
weeks, patients were assessed for post-operative SNOT- 20 scores,
Kupferberg endoscopic staging, AEC, and Serum IgE.
The patients who were available for follow-up were followed up at twelve
weeks and twenty four weeks even after the study period of six weeks.
After six weeks, patients in both groups continued to use Fluticasone
nasal spray.