Primary Endpoint
Both study groups had effective adherence to treatment, the percentage of pills used was median (IQR) of 100.0% (98.0% to 100.0%) in the betahistine arm and a median (IQR) of 100.0% (96.0% to 100.0%) in the placebo arm. There was no difference in the THI change (THI before and after intervention) between the study groups (median difference of -2 points; 95.0% CI, -8 to 6 points) (U = 458.5, P =.75). The THI after the intervention was a median (IQR) of 4 (-4 to 14) points lower than before intervention in the betahistine arm and a median (IQR) of 2 (-6 to 10) points lower than before intervention in the placebo arm (Table 2; Figure 2).