Limitations
As a single-centre study at a district general hospital, we cannot generalise our results to other settings. Furthermore, our trust is based in southern England, where population demographics and socioeconomic status may differ from those elsewhere.
We also acknowledge that extracting information from medical notes requires second-hand interpretation and may not be representative of the full clinical picture. The Rockwood Clinical Frailty Score was not included because of the potential inconsistencies in interpretation.
Considerations were made for the utilisation of sample size calculations to ensure the study was powered appropriately. Despite achieving significant results in a number of outcomes, we acknowledge the risk of a type 2 error occurring with our experimental sample size. Therefore, we were unable to discount an association between polypharmacotherapy, ACB and those variables which did not achieve statistical significance with observed effect sizes.