1.Introduction
In biology and other experimental sciences, an Insilico experiment is one performed on computer or via computer simulation.  The phrase is pseudo-Latin for ’in silicon’ (in Latin it would be in silicio), referring to silicon in computer chips. Actually In silico study helps us to estimate effectiveness of hypothesizes before doing any animal and clinical trials, so it can reduce the risk of animals and people death.2 By estimating the bond energies, scientists can assure the possibility of protein – ligand interactions and drug activity. As an example, this technique could be utilized to study antiviral effects of candidate drugs to cure coronavirus disease (COVID-19) caused by SARS-COV-2. COVID - 19 is an infectious disease caused by a novel SARS-CoV-2 pandemic which initially started in Wuhan province in China and has now affected > 200 countries worldwide and declared a pandemic. 1,3,4 As per the statistics available, mortality is high in older age group individuals (> 60 years of age) and people with other morbid conditions. In addition to acute respiratory distress syndrome and respiratory failure, COVID-19 is now known to manifest as systemic inflammation, leading to sepsis, acute cardiac injury, and heart failure and multi-organ dysfunction in patients at high risk.3Metal oxide nanoparticles with their novel properties have had increasing interest for these kinds of biomedical applications. In recent years, monodispersed super paramagnetic iron oxide nanoparticles were developed for various biological applications such as antiviral activity , drug delivery, protein purification, MRI and hyperthermia treatment.5,6 Magnetic nanoparticles with a size range of less than 1000 nm have been used to treat proteins (5–50 nm), genes (10– 100 nm), viruses (20–450 nm) and cells (10–100 mm) without any difficulty. The advantages associated with super paramagnetic nano particles are easy preparation, active surface functionality, chemical stability, fast response under an external magnetic field, low toxicity and cost effectiveness. However, it is difficult to use pure Fe3O4 nanoparticles for these applications due to their high surface to volume ratio, strong dipole–dipole interaction between the particles and agglomeration.7All these problems were solved by encapsulating the iron oxide nanoparticles in surface active agents. The encapsulation provides improved chemical, mechanical, solubility and biological stability to the environment, so based on this information, modified magnetic nanoparticles were used as a treatment for COVID – 19 in this work. In the first step the interactions (ligand – receptor = drug – target protein) were confirmed by aid of Insilco assay.8 The Insilico assay results are described in this paper in details. Not any available ligand structure in databanks was used to design the drug and all information about suggested drug are noble.