Figure (7) interactions of Ligand 4
Information about ligand –protein bond energies (Hydrogen bonds – steric bonds – total energies) and affinity of ligand to protein as the receptor is summarized in table 3. This information approves the antiviral effects of ligands. Totally Docking, as a method to estimate possible ligand- receptor interactions, was done by different applications such as Auto dock 4.2, MOE 2019, Molegro virtual docker 2013 and online servers to approve designed ligands have antiviral effect by making interactions with SARS -COV -2 spike glycoprotein and interfering viral entry.