Introduction
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) classified
by the World Health Organization in March 2020 [1], has become an
outbreak around the world. However, compared to adults, the coronavirus
disease 2019 (COVID-19) may less impact the pediatric population with
most having a milder symptoms [2]. In general, COVID-19 in children
very less than adults, haematological disease following SARS-CoV-2
infection in pediatric patients is rare. Here, we reported a
pediatric case who developed B cell
acute lymphoblastic leukemia (B-ALL) following mild SARS-CoV-2
infection. A Chinese family was diagnosed as mild type of COVID-19
infection in Belarus. Without any treatment, SARS-CoV-2 RNA and
COVID-19-specific antibodies IgM were
negative after two weeks. But the boy in this family showed bone pain
and pancytopenia after nineteen days from diagnosed COVID-19. With basic
supportive treatment, his symptoms and hemograms returned to normal.
Previous symptoms appeared again with significantly elevated white blood
cells. As well, blast cells also experienced transient decline and
increased again without any treatment. For further diagnosis and
treatment, they were back to China. Eventually laboratory findings
confirmed B-ALL in Beijing Children’s hospital.