RESULTS:
The original search retrieved 689 unique citations; six additional
articles were found via references and three via Pubmed alerts, of which
52 were full-text screened. The final search retrieved 8 additional
articles, which were full-text screened. Overall, 17 studies were
included (Fig. 1 and 2, and Table 1). Of them, three were randomized,
double-blinded, placebo-control (RDBPC) studies17-19,
five quasi-experimental prospective cohorts20-24, five
prospective cohorts25-29, two retrospective
cohorts30,31, and two case
reports32,33.
Participants with hazelnut allergy were included in 14 studies, walnut
in 1 17,18,20,21,23-27,33, cashew in
917,18,20,21,23-27, pecan in
717,18,20,21,24-26, almond in
517,20,21,26,27, and pistachio in
517,18,23,27,32.
The population in question was adults in three
studies19,28,32, children in
514,17,27,31,33, and both in
918,20-26,29.
A detailed description of all the included studies, and studies that
might appear to meet the inclusion criteria, but which were excluded,
can be found in the Supplementary text.
Efficacy and safety