2.3 Study endpoints
The primary endpoints were maximum plasma concentration of SHR2554 (Cmax), area under the plasma concentration-time curve (AUC) from time 0 to the time of the last quantifiable concentration (AUC0-t), and AUC from time 0 to infinity (AUC0-∞), the secondary endpoints included other PK parameters, such as time to reach Cmax(Tmax), terminal elimination half-life (t1/2), apparent clearance (CL/F), and apparent volume of distribution (Vz/F); and safety endpoints, including incidence and severity of AEs, and evaluation through laboratory tests, physical examination, vital signs, and 12-lead ECG. The SHR2554 main metabolites were quantitatively analyzed. All the definitions and calculations were provided in the supplementary.