Treatment period
Parent
Cmax (ng/mL)
Tmax (h)
AUC0-t (ng*h/mL)
AUC0-∞ (ng*h/mL)
t1/2 (h)
CL/F (L/h)
VZ/F (L)
SHR2554 (300mg) alone N=17 177.2 (72.0%) 1.5 (1.0-4.0) 672.1 (75.4%) 721.5 (71.2%)b 6.5 (36.4%) 651.4 (56.8%) 6651.3 (85.4%)
SHR2554 (300mg) + rifampin (600mg) N=17 17.0 (49.8%) 1.5 (0.5-4.0) 38.5 (50.5%) 46.3 (44.8%)c 2.6 (35.0%) 8134.9 (43.1%) 30423.5 (52.4%)