Antenatal markers and neonatal events in association to lung function
In very preterm infants, antenatal events associated with BPD (chorioamnionitis and maternal infection) were not associated with impaired lung function at 12 years of age, neither was premature rupture of membrane.
Children that had been mechanically ventilated in the neonatal period showed increased airflow obstruction at school age; FEV1(p=0.005) and FEF25-75 (p=0.027). These children also had lower diffusing capacity, DLCO (p=0.005), DLCO % of predicted (p=0.019), KCO(p=0.16) and KCO % of predicted (p=0.034). Surfactant treatment was not associated with later lung function impairment.