Prognostic factors
Univariate analysis of prognostic factors revealed that liver metastases (P <0.01) and brain metastases (P <0.01) were associated with death in GTN patients. Other prognostic factors including non-molar pregnancy (P<0.05), interval from antecedent pregnancy to chemotherapy >12 months (P<0.01), pre-therapy serum β-hCG >105 (P<0.01), tumor size including uterus ≥5 cm (P<0.01), >8 metastases (P<0.01), history of failed multidrug chemotherapy failure (P<0.01), FIGO III and IV stage (P<0.01), and FIGO score >13 (P<0.01).
Multivariate analysis (excluding FIGO stage and FIGO score) revealed that liver metastases (HR: 34.05; 95% CI: 1.65–703.7;P <0.05) and brain metastases (HR: 49.19; 95% CI: 5.6–432.1; P <0.01) were independently significant risk factors for death in all patients with GTN (Table 1).