Chemotherapy
Ten patients received first-line EMA-CO treatment, and one was treated
with EMA-EP chemotherapy. TP/TE, BEP, and EMA-EP were the most common
used salvage chemotherapy regimens for GTN patients with liver or brain
metastases. All GTN patients with brain metastases (n=8) received a
combination of systemic chemotherapy (EMA-CO or EMA-EP) and intrathecal
injection of methotrexate (Table 2). A further two to four courses of
consolidation chemotherapy were administered to patients with
normalization of serum and CSF β-hCG levels (Table 2).