Prognostic factors
Univariate analysis of prognostic factors revealed that liver metastases
(P <0.01) and brain metastases (P <0.01)
were associated with death in GTN patients. Other prognostic factors
including non-molar pregnancy (P<0.05), interval from
antecedent pregnancy to chemotherapy >12 months
(P<0.01), pre-therapy serum β-hCG
>105 (P<0.01), tumor size
including uterus ≥5 cm (P<0.01), >8 metastases
(P<0.01), history of failed multidrug chemotherapy failure
(P<0.01), FIGO III and IV stage (P<0.01), and FIGO
score >13 (P<0.01).
Multivariate analysis (excluding FIGO stage and FIGO score) revealed
that liver metastases (HR: 34.05; 95% CI: 1.65–703.7;P <0.05) and brain metastases (HR: 49.19; 95% CI:
5.6–432.1; P <0.01) were independently significant risk
factors for death in all patients with GTN (Table 1).