Author, year (Ref.)
Research type
Object*
Sample size
Factors
Gene
CpG sites
Method
Main result** (P value)
Xu, R. 2021[13] cohort study H 954 mother smoking CYP1A1 8 sites 850K array significant hypomethylation
Aung MT 2021[14] cohort study H 97 trace metals in blood CYP24A1 cg02143877 450K array β=5(8.2×10-9
Waalkes, M. P. 2004[15] controlled experiment H&M 7 placental arsenic CYP2A4 13 sites BSP followed by cloning PCR products on plasmids hypomethylation
Bahl, A. 2015[16] cohort study H 40 placental hormone ABCA1 /*** 450K array under-represented
Hogg, K. 2013[17]
cohort study
H
161
placental hormone
CYP11A1NR3C1 CYP19
4 sites
bisulfite pyrosequencing
in appendix
Huang, J. Y. 2017[18] cohort study H 589 maternal gestational weight gain ABCA1 / Epityper hypomethylation
Veenendaal, M. V. 2012[19] cohort study H 759 prenatal hunger PPAR-α / methyquant hypermethylation
Talens, R. P. 2012[20]
multicenter RCT Study
H
248
prenatal hunger
ABCA1
/
Epityper
non-significant (0.093)
Witt, S. H. 2018[21]
cohort study
H
282
mother smoking
CYP1A1
cg05549655
450K array
differences=0.021 (4.76×10-5)
Houde, A. A. 2013[58] cohort study H 100 LDL-C and TG ABCA1 2 sites bisulfite pyrosequencing in appendix
Zhao, N. 2019[59]
controlled experiment
M
20
Maternal betaine exposure
CYP7A1
/
MeDiP✟*
hypermethylation (<0.05)
Yan, Z. 2014[50] controlled experiment M 39 polycyclic aromatic hydrocarbons PPAR-γ 3 sites bisulfite pyrosequencing in appendix
Miura, R. 2018[60]
controlled experiment
H
190
prenatal perfluoroalkyl substance exposure
SLC9A4 CYP2E1
/
450K array
in appendix