Author, year (Ref.)
Research type
Object*
Sample size
Factors
Gene
CpG sites
Method
Main result** (P value)
Lei Zhang, 2016[43]
controlled experiment
M&C
4
berberine
CYP2B6 CYP3A4
13 sites
MeDiP, Epityper
hypomethylation
Wang, X. K. 2014[47] controlled experiment C 30 afatinib ABCG2 / BSP followed by cloning PCR products on plasmids hypermethylation
McLaughlin, P. 2017[45]
cohort study
H
21
methadone
ABCB1 CYP2D6
/
bisulfite pyrosequencing
hypermethylation
Martín, V. 2013[71] controlled experiment C / melatonin ABCG2 / MSRE-qPCR hypermethylation
Lin, R. 2013[72]
controlled experiment
C
40
cisplatin
SLC22A1 SLC22A2 SLC22A3
/
MSP
hypermethylation
Li, X. 2017[44] cohort study H 438 aspirin ABCB1 CpG21,22 bisulfite pyrosequencing significant
García-Calzón, S. 2017[46]
cohort study
H
42
metformin/ insulin
SLC22A1 SLC22A3 SLC47A1
31 sites
450K array
in appendix