5 Conclusion
In a word, clinical suspicion of AIFRS should be alert in the immunocompromised patient presenting with new-onset, rapidly progressive sinusitis with facial-cranio-orbital spread. A multidisciplinary approach consisting of antifungal therapy, surgical debridement, immunodeficiency reversal, and supportive treatment were essential to improve the control. We need more focus on comprehensive assessment, an extended debridement such as maxillectomy and orbital exenteration should be considered on a case-by-case basis. The outcome of AIFRS with facial-cranio-orbital involved was usually fatal which mainly defined by the underlying disease.