1 Introduction
Acute invasive fungal rhinosinusitis (AIFRS) are rare events which generally occurs in immunocompromised patients, management of such disease means great challenge to ENT doctor because of its dangerous outbreak and poor general condition, with mortality up to 50-80%[1,2].
The concept of invasive fungal infection refers to the invading of fungal hyphae to epithelial tissue, bone, with potential neural and vascular invasion. It generally classified into chronic invasive fungal rhinosinusitis (CIFRS) and acute invasive fungal rhinosinusitis (AIFRS). CIFRS is an indolent infection with a slow destructive process while AIFRS is defined by a time course of less than 4 weeks’ duration, with predominant vascular invasion and fast spread which need an urgent management.
In this paper, by analyzing the clinical features, management and follow-up of 8 AIFRS patients with orbit-cranio-facial invasion, we aimed to share clinicians with our experience on how to manage such a disease and discuss the main factors which predict the survival outcomes.