3.3 β-endorphin is a biomarker of itch in arsenic-exposed participants
The characteristics of the participants are shown in supplementary Table S3. Among the 8 mediators of itch, we identified serum β-endorphin as a significant biomarker that was does-dependently associated with the intensity of itch in arsenic-exposed participants in Shimen (Figure 3). In contrast, the levels of substance P, nerve growth factor, histamine, interleukin-31, IgE, endothelin-1, and 5-hydroxytryptamine were not statistically different among the three groups.