Conclusion
COVID-19 vaccination with COVISHILED and COVAXIN resulted in menstrual cycle disturbances including changes in cycle length, duration, and amount of bleeding and pre-and post-menstrual symptoms. Menstrual cycle irregularities including length were significantly higher in the COVAXIN group, whereas pre-and post-menstrual symptoms were more commonly observed with the COVISHIELD vaccine. No significant difference was observed in the incidence of COVID-19 infection in either group. Furthermore, no significant association was found between COVID-19 infection and menstrual cycle changes. Hence, COVID-19 vaccines can affect menstrual cycle patterns and lead to new-onset pre- and post-menstrual symptoms in women, but for what duration these changes will last post-vaccination need to be further evaluated.