Safety profile and adverse reactions
EPIT was well-tolerated, and neither systemic or severe local reactions were recorded. All side-effects were local and self-limiting. Pruritus was the most frequently observed side-effect, reported by five owners. Of note, dogs were not used to wearing cotton bodysuits, so it is unknown whether it interfered with pruritus reaction. Non-pruritic erythematous reactions were observed under the patch in three dogs (two mild, one moderate) following the 50HEP/mL dose, and once in two dogs (both mild) with the 100HEP/mL dose (second application). One dog presented mild-grade pustules under the patch after two consecutive applications. No reactions required therapeutic intervention.