Primary efficacy outcomes
There were no statistical differences between breeds for all the
parameters evaluated.
After 6-month EPIT, all dogs had
reduced pruritus scores, with a 63.1% mean improvement, and 13/15 dogs
improved their severity level, while two dogs maintained their
moderate-to-severe level. Of note, 4/8 dogs starting the study with a
severe pruritus concluded the 6-month EPIT with a normal status (table
1). Moreover, all dogs showed improved pruritus scores (56.1% mean
improvement) and severity level at three months, including the two dogs
that maintained their initial moderate-to-severe level at six months,
but were normal-to-mild at three months. According to the success
criteria, 73.3% of dogs (11/15) succeeded in pruritus evaluation at six
months.
Regarding skin lesions’ evaluation, 9/15 dogs (60%) improved in
severity after EPIT, with a 56.5% mean improvement, whereas 5/15 dogs
(33.3%) maintained their initial normal (2/3) or mild (3/6) range.
Furthermore, at both three- and six-month timepoints, all but one dog
were in the normal-to-mild range, and no dog was severe (table 2). After
EPIT, 66.7% of dogs (10/15) succeeded in skin lesion evaluation,
considering the defined criteria.
Concerning OGATE, 14/15 owners rated the response to EPIT as
good-to-excellent, ranking success as 93.3%, while the remaining owner
assessed it as a fair response.
Over six months, EPIT significantly improved mean PVAS10 scores from
5.27±1.81 to 2.15±1.83 (p=0.000015), as that of 2D-IGA from 2.40±1.06 to
1.67±0.62 (p=0.006). Noteworthy, a significant improvement was evident
after one month of treatment for both PVAS10 (p=0.003) and 2D-IGA
(p=0.009) scores (table 3, figure 3).