Statistical Analysis
Statistical analysis was performed using GraphPad Prism 5 (La Jolla, CA), and the data are displayed as the means ± SD. Student’s t test and two-way ANOVA was applied to assess the statistical significance. A value of P <0.05 was considered statistically significant (*P < 0.05; **P <0.01; ***P < 0.001; ****P < 0.0001).