Data Synthesis and Analysis
The synthesis of results was performed using the Guidance on the Conduct
of Narrative Synthesis in Systematic Reviews (Popay et al., 2006). The
outcomes regarding platinum ototoxicity symptom ease were reported using
means (or difference in means) ± standard deviations or means with
confidence intervals (CIs) and p values. Epidemiological
statistics were reported according to the original articles. The data is
presented regarding the efficacy and safety of each intervention.
Furthermore, to improve intervention comparisons, the summary
information underlines the intention of the intervention
(prevention/treatment), the type of assessed ototoxicity (hearing loss,
tinnitus, and/or vestibular disturbances), and if other ototoxic
treatments were associated with the platinum treatment (e.g.
radiotherapy with Gray dose). All authors were involved in analyzing and
interpreting the results and vouch for their completeness and accuracy.