Data extraction
Three reviewers (EQ, JEC, and LB)
independently extracted data into a Microsoft Excel spreadsheet. Data
extracted included the year of publication, country, study design,
number of participants, inclusion/exclusion criteria, sample
characteristics, type of cancer, patient’s functionality, chemotherapy
agent, dose average, number of cycles, concomitant radiotherapy
exposure, audiometric measurements, kind of ototoxicity, type of
intervention, comparator, time of follow-up, and efficacy and safety
outcomes. To ensure consistency, extracted data were compared between
reviewers, and disagreements were discussed until a consensus was
reached.