Introduction

Hepatoid carcinoma is a rare type of malignant tumor with morphologic characteristics similar to HCC, arising outside the liver, most commonly in the stomach and less in the ovary, uterus, lung, bladder or kidney(1). In 1987, Ishikura and Scully first reported five cases of HCO, mainly in postmenopausal women who presented with an ovarian mass and elevated serum AFP(2). The microscopic characteristics of these tumors are sheets, trabeculae and cords of cells with moderate to large amounts of eosinophilic cytoplasm and round to oval central nuclei(3). HCO must be distinguished from the HCC metastatic to the ovary(4) and other ovarian tumors with abundant eosinophilic cytoplasm, including hepatoid yolk sac tumors (HYSTs)(5), Sertoli–Leydig cell tumors, and oxyphilic clear cell carcinomas. We describe an additional case of a 64-year-old postmenopausal Chinese woman diagnosed with HCO, featuring with significantly elevated serum AFP and CA125 level.