Introduction
Hepatoid carcinoma is a rare type of malignant tumor with morphologic
characteristics similar to HCC, arising outside the liver, most commonly
in the stomach and less in the ovary, uterus, lung, bladder or
kidney(1). In 1987, Ishikura and Scully first reported five cases of
HCO, mainly in postmenopausal women who presented with an ovarian mass
and elevated serum AFP(2). The microscopic characteristics of these
tumors are sheets, trabeculae and cords of cells with moderate to large
amounts of eosinophilic cytoplasm and round to oval central nuclei(3).
HCO must be distinguished from the HCC metastatic to the ovary(4) and
other ovarian tumors with abundant eosinophilic cytoplasm, including
hepatoid yolk sac tumors (HYSTs)(5), Sertoli–Leydig cell tumors, and
oxyphilic clear cell carcinomas. We describe an additional case of a
64-year-old postmenopausal Chinese woman diagnosed with HCO, featuring
with significantly elevated serum AFP and CA125 level.