Case report
A 61-year-old woman, with no medical history, was diagnosed with viral hepatitis C and started treatment with the combination ledipasvir sofosbuvir in June 2020, 400 mg per day.
Five weeks after starting the treatment, she developed a slightly itchy erythematous rash on lower members. The patient initially suspected the treatment and she stopped it.
Physical examination revealed purpuric lesions with confluent erythematous macules at the lower third of the thighs reaching the knees. Lesions were symmetrical. Skin biopsy was performed. Histological finding revealed a diffuse neutrophile infiltration of vessel walls confirming leucocytoclasic vasculitis.
Lesions disappeared completely three days after drug withdrawal without any symptomatic treatment.