Discussion
Our method has been applied as “compassionate use” in difficult
clinical cases. To be honest, we did not expect to see a quick and final
(permanent?) result. At first, we intended to administer the micro-ECP
until the patient’s condition improved, with the subsequent transition
to standard ECP. However, this was not required. The amazing response we
were able to achieve with a minimum number of cells, inspired us to
continue the therapy in the form of micro-ECP, which was justified. Both
patients completely recovered from GVHD.
The micro-ECP method needs further research. It is necessary to
understand for whom it can be effective, for whom it will not help, and
what variables influence the effectiveness of therapy. ECP, developed
more than 30 years ago, still excites our minds and provides the ground
for the extension of clinical investigation
Figure 1. Patients treatment history.