Discussion
Our method has been applied as “compassionate use” in difficult clinical cases. To be honest, we did not expect to see a quick and final (permanent?) result. At first, we intended to administer the micro-ECP until the patient’s condition improved, with the subsequent transition to standard ECP. However, this was not required. The amazing response we were able to achieve with a minimum number of cells, inspired us to continue the therapy in the form of micro-ECP, which was justified. Both patients completely recovered from GVHD.
The micro-ECP method needs further research. It is necessary to understand for whom it can be effective, for whom it will not help, and what variables influence the effectiveness of therapy. ECP, developed more than 30 years ago, still excites our minds and provides the ground for the extension of clinical investigation
Figure 1. Patients treatment history.