Abstract
Extracorporeal photopheresis (ECP) has proven effective in the treatment
of several diseases, including acute and chronic graft-versus-host
disease (GVHD) after allogeneic hematopoietic stem cell transplantation.
In its standard version, ECP requires leukapheresis to obtain a fraction
of mononuclear cells. The possibility of using leukapheresis is limited
by the requirements for vascular access and the somatic status of the
patient.
We have developed a new ECP method that does not require leukapheresis.
This paper presents a description of two clinical cases of severe
refractory GVHD treated by micro-ECP.