6. Conclusion
In this study, we have established and validated a method to determine
the concentration of TGC in serum and CSF. This method could achieve the
quantification accurately in 2.5 min. We quantified the bio-samples from
12 MDRAB CNSI patients treated with TGC to evaluate CSF-to-serum ratio
of TGC at steady-state trough concentration. And the correlation between
the concentrations of TGC in CSF and serum at steady-state was
demonstrated to be positive. CNSI also did not show the potential to
increase the penetration ability of TGC to CSF.