Abstract
Alzheimer’s Disease is an ailment
that is linked with the degeneration of the brain cells and this is the
main cause of dementia. The occurrence of AD will significantly surge as
the world’s population will age along with lifestyle changes perceived
in current decades giving the impression of main contributors to such
augmented prevalence. Similarly, metabolic disorders of current
adulthood, such as obesity, liver, stroke, and diabetes mellitus, have
been observed as the risk-causing factors of AD. FOXO transcription
factors are preserved molecules that play an important part in assorted
biological progressions, precisely in aging as well as metabolism. Here,
we capitulate the signaling pathways along with the cellular functions
of FOXO proteins. We have also summarized the intricate role of FOXO in
AD, with a focus on metabolic stress, and discussed the prospect of
transcriptional alterations with respect to FOXO as a molecular link
between AD and metabolic disorders.
Keywords: Alzheimer’s Disease; FOXO; Liver; Diabetes; Obesity;
Oxidative stress