6.1.2 Inhibition of apoptosis
In the process of apoptosis, Bcl-2 plays a crucial role. It has been
reported that H2S is able to reduce the proportion of
apoptotic cells in the myocardium of I/R mice by upregulating the
expression level of Bcl-2 and decreasing the expression of Bax and
cystein 3[116]. Apoptotic proteins (IAPs) can
block the apoptotic cascade response, and it has been found that
H2S can inhibit apoptosis by affecting the
phosphorylation of IAPs and cysteine aspartase recruitment structural
domains.