6.1.2 Inhibition of apoptosis
In the process of apoptosis, Bcl-2 plays a crucial role. It has been reported that H2S is able to reduce the proportion of apoptotic cells in the myocardium of I/R mice by upregulating the expression level of Bcl-2 and decreasing the expression of Bax and cystein 3[116]. Apoptotic proteins (IAPs) can block the apoptotic cascade response, and it has been found that H2S can inhibit apoptosis by affecting the phosphorylation of IAPs and cysteine aspartase recruitment structural domains.