6.1.3 Autophagy
Hydrogen sulfide protects cardiomyocytes through a bidirectional action in autophagy[117]. Tissue or cellular ischemia leads to the development of cellular autophagy, and moderate cellular autophagy facilitates the repair of damaged cells. It has been demonstrated that hydrogen sulfide can exert cytoprotective effects by promoting autophagy, which seems to be associated with NLRP3 inflammatory vesicles. Excessive autophagy exacerbates cellular I/R injury, and H2S can activate PI3K/SGK1/GSK3β signaling pathway and PI3K/Art/mTOR signaling pathway to inhibit autophagy and provide protection for I/R-injured cardiomyocytes[118, 119].