6.1.1 Antioxidant
The massive production of ROS during reperfusion is the main cause of a
series of oxidative stress responses, however, H2S can
inhibit its production by regulating ROS signaling pathways, such as
inhibiting NF-κB and JAK2-STAT3 pathways to reduce ROS
levels[113].At the same time, H2S
can also increase the expression levels of superoxide dismutase (SOD)
and glutathione (GSH) in I/R tissues, both of which are antioxidant
enzymes that protect cardiomyocytes by converting peroxides
(H2O2)[74, 114].
In addition H2S can promote nuclear translocation of
nuclear factor-E2-related factor-2 (Nrf2), an important antioxidant
transcription factor that increases transcription of antioxidant
proteins and reduces apoptosis and mitochondrial
damage[115].