6.4 Hepatoprotective effects of hydrogen sulfide
Ischemic liver tissue is extremely susceptible to more severe liver
dysfunction and failure after reperfusion occurs[157,
158]. More seriously, hepatic ischemia-reperfusion(HIR) can also
affect the success of liver resection or transplantation and increase
the risk of death for the operator[157, 159]. The
risk of death is increased. There is a lot of experimental data to
demonstrate that H2S can effectively protect liver
tissue in hepatic I/R injury and is expected to be a new way to reduce
the morbidity and mortality of hepatic I/R injury
complications[160-162]. Some experiments have
shown that the expression levels of endogenous H2S and
CSE are elevated in the tissues of HIR rats, and the researchers
speculate that this may be due to the self-protective response of the
organism induced by HIR. Meanwhile, after using the exogenous
H2S donor NaHS in HIR rats, the investigators found that
NaHS could attenuate I/R-induced liver injury[160,
163] At present, there has been a large amount of data demonstrating
that H2S can play a role in reducing liver injury
through various mechanisms, such as inhibition of oxidative stress,
anti-apoptosis, anti-inflammation, protection of mitochondrial function
and regulation of autophagy[164-169]. However, it
has also been found that endogenous H2S may exacerbate
HIR-induced liver injury in the context of insulin resistance, so
H2S should be used with caution in this
situation[170].