4.1 Sulfates
Sulfalts are currently the most common hydrogen sulfide donors in
biological research, such as sodium sulfide and sodium hydrosulfide,
which have been shown to have protective effects on cells in disease
states in multiple studies[44]. Both sodium
sulfide and sodium hydrosulfide exhibit crystalline powder appearance,
which is easily soluble in water and can provide hydrogen sulfide more
directly. In early studies, Wang et al. used NaHS aqueous solution to
release H2S and found that it can reduce systemic
arterial pressure, indicating that hydrogen sulfide has the
characteristic of relaxing blood vessels[45]. This
has been verified in the research of Daniel et al., in addition, they
also found that the reduction of hydrogen sulfide donors will lead to
the reduction of cardiac output, which will lead to the reduction of
systemic arterial pressure, and this phenomenon does not depend on the
regulation of the central nervous system[46]. In
multiple studies, hydrogen sulfide released by exogenous donor NaHS can
play a protective role in organ damage, such as myocardial
damage[47,
48],liver[49],brain[50],kidney[48]et.
However, the chemical properties of sulfide salts are not stable, and
the dosage and speed of hydrogen sulfide produced after direct
dissolution in water are uncontrollable. The release of a large amount
of hydrogen sulfide can cause a sudden drop in blood pressure, which has
adverse effects on experimental animals.