Participants
Healthy subjects ≥18 and ≤65 years-of-age were enrolled with body mass index ≥18.5 and ≤32.0kg/m2 and body weight ≤120kg. Participants had to be willing/able to provide consent and adhere to trial requirements. All participants of childbearing potential were on acceptable birth control. Main exclusion criteria were estimated: creatinine clearance <90mL/min, history of clinical hypersensitivity or allergy to any pharmaceutical agent, chronically administered antihistamines or corticosteroids within the last 28 days, and significant mental illness. Tattoos, scarring, or other abdominal skin characteristics which could confound assessment of ISRs were also considered exclusion criteria.