Results
The absolute-prevalence and -incidence of reported drug allergy was
5.61% and 277/100,000 population in 2021, respectively. Annual
incidence of newly reported drug allergy was stable between 2016-2019,
until a significant drop in 2020 (-16.3%, p=0.037). The most common
implicated drugs were anti-infectives (245,832 [44.5%]), NSAIDs
(106,843 [19.3%]), and nervous system drugs (45,802 [8.3%]).
There was significant higher incidence among individuals aged
>40, contributing to the majority of newly reported
allergies (377,004, 68.2%). Beta-lactams and nervous system drugs were
the most common reported culprits of anaphylaxis and Stevens-Johnson
syndrome. CEDAR was unable to confirm presence or absence of PEG in any
of the top reported culprits due to insufficient excipient information.