Construction of excipient allergy registry – using PEG as an
example
An excipient registry was constructed based on the top 50 reported drug
allergy culprits as retrieved from CEDAR. In view of the recent
relevance for mRNA vaccines, PEG was selected as the pilot registry. An
excipient registry was created by compiling the excipient lists
pertaining to all available formulations of each of the drugs of the top
50 most implicated drug allergies. All excipient lists from drug product
inserts, and if unavailable, through contacting individual
pharmaceutical companies - as there is no pharmaceutical legislation to
mandate listing of excipients of registered drugs in Hong Kong.
Depending on the status of PEG, formulations were then categorised as
either ‘contains PEG’, ‘does not contain PEG’, or ‘unknown’.