Most common reported drug allergies were to beta-lactams, making up 26.0% of all labels
Out of the 552,897 reported drug allergy labels, the most common implicated drugs were anti-infectives (245,832 [44.5%]) and NSAIDs (106,843 [19.3%]), followed by nervous system drugs (45,802 [8.3%]) and cardiovascular system drugs (27,977 [5.1%]) (Figure 2). Among the 245,832 reported anti-infective allergy labels, 143,925 (58.5%) were towards beta-lactams (Table 1). Among beta-lactams, penicillins accounted for the vast majority (119,274 [82.9%]) of reported culprits. Amoxicillin-clavulanate was the most commonly reported (30,396 [21.1%]), followed by phenoxymethylpenicillin (penicillin V) (25,678 [17.8%]), amoxicillin (21,806 [15.2%]), ampicillin (16,335 [11.3%]), and cloxacillin (9,689 [6.7%]).