Results
The absolute-prevalence and -incidence of reported drug allergy was 5.61% and 277/100,000 population in 2021, respectively. Annual incidence of newly reported drug allergy was stable between 2016-2019, until a significant drop in 2020 (-16.3%, p=0.037). The most common implicated drugs were anti-infectives (245,832 [44.5%]), NSAIDs (106,843 [19.3%]), and nervous system drugs (45,802 [8.3%]). There was significant higher incidence among individuals aged >40, contributing to the majority of newly reported allergies (377,004, 68.2%). Beta-lactams and nervous system drugs were the most common reported culprits of anaphylaxis and Stevens-Johnson syndrome. CEDAR was unable to confirm presence or absence of PEG in any of the top reported culprits due to insufficient excipient information.