Figure 1
(A) CKLF Like MARVEL Transmembrane Domain Containing 4 (CMTM4)
protein adapter is constitutively and specifically associated to IL-17
receptor C (IL-17RC) and it is essential for full glycosylation of the
receptor molecule and the trafficking to trans-Golgi up to plasma
membrane. Upon IL-17A stimulation, IL-17RC forms heterodimer with IL-17
receptor A (IL-17RA) and activates intracellular signaling cascade.(B) In Cmtm4−/− mice the expression of
IL-17RC is specifically downregulated in the keratinocytes. (C)In Imiquimod (IMQ)-induced psoriasis mouse model,Cmtm4−/− mice developed less severe psoriatic
lesions and lower local expression of IL-17A target genes compared toCmtm4+/+ mice. (D) MOG-induced model
of experimental autoimmune encephalomyelitis (EAE),Cmtm4−/− and Cmtm4+/+mice displayed comparable EAE severity score.
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