Contributions
Rf, MH, JAE conceived the study, NC, HH, MH, OH, PK, EM, OP, ADS contributed to provide samples. RF conducted laboratory analysis and bioinformatics under supervision of MH and JLAP, and  RF drafted the manuscript as part of his PhD supervised by JAE and MH. JAE, JLAP and MH read and commented on several earlier versions. All authors read and improved the joint manuscript.