Statistical analysis
All data were analysed using Prism 9 software (GraphPad Software; Boston, MA, USA). Data from two groups were analysed by unpairedt test, while data from more than two groups were analysed by one-way ANOVA with Tukey’s multiple comparisons test with a single pooled variance. Unless otherwise stated, differences are statistically non-significant. **** p <0.0001, *** p<0.001; ** p <0.01; * p<0.05.