3.3 Data mining
The characteristics of venous
thrombosis adverse event cases and antipsychotic drugs were collected,
including age, sex, reporter, report country, report year, case outcome
Reporting odds ratio (ROR, a frequency method) and the information
component (IC, a Bayesian approach) were used to detect the ”signal” (a
significant association between venous thrombosis adverse event and
antipsychotic drugs). For ROR, a signal is detected if the case number
is ≥ 3 and the lower limit of the two-sided 95% confidence interval
(95% CI) is > 1. For the IC, a signal is detected if the
lower limit of 95% CI is > 0. Both methods were used for
signal detection, and venous thrombosis adverse event was considered
drug-associated if ROR and IC met the above-mentioned criteria.