3.1 Data source
The FAERS datasets comprises seven data tables, including patient demographic and administrative information (DEMO), drug information (DRUG), adverse events (REAC), patient outcomes (OUTC), report sources (RPSR), therapy start states and end dates for reported drugs (THER), and indications for drug administration (INDI). Raw FAERS data can be downloaded for free from the FDA website. Data from the first quarter of 2004 to the end of 2021 were downloaded from the FAERS Quarterly Data Extract Files [10]. Duplicate records were excluded based on FDA recommendations. If the CASEIDs (a number for identifying a FAERS case) were the same, the latest FDA_DT (date FDA received the case) was selected. If the CASEID and FDA_DT were the same, the higher PRIMARYID (a unique number for identifying a FAERS report) was established. Deleted cases from 2019 were further removed from the local database. FAERS data were managed locally using Microsoft SQL Server 2017.
3.2 Antipsychotic drugs and venous thrombosis adverse event identification
Drug names in the DRUG table can be documented in various forms, including generic, brand, synonymous, or abbreviations. Before identifying target drugs, we standardized different names of the same drug into a ”generic name” using MedEx software (MedEx UIMA 1.3.8, Vanderbilt University, USA)[11, 12]. We attempted to identify 47 single-component antipsychotic drugs according to the WHO Anatomical Therapeutic Chemical (ATC) classification (ATC code: J01AA) from the local FAERS database. The 47 agents (ATC codes)( Supplementary Information for detail)