Author Study Type, Total sample size Intervention Route of administration Indication / Treatment or prevention Agents
1
Liang Yan et al 2011 Quasi-RCT N =62
Early oral care
Topical
Prevention and treatment
Multi- agent management using normal saline, yingertong, gentamicin, metronidazole and dexamethasone Appropriate dietary and nutritional measures
2
Hu ping et al 2011
RCT N = 76 patients (32 control group, 44 treatment group)
Oral care (multi-drug)
Topical and PO
Treatment
Multi-agent management using normal saline or 5% sodium bicarbonate gargle, Ultrasonic atomization of 3-5mls of distilled water, smecta powder and lidocaine. Appropriate dietary and nutritional measures Psychological support
3
HE Yuan et al 2019 RCT N = 52 patients (26 control group, 26 treatment group)
Oral care (multi-drug)
Topical and PO
Treatment
Multi- agent management using 2% sodium bicarbonate solution gargle, yinertong, recombinant human epidermal growth factor spray, Kangfuxin and Vit C Appropriate dietary and nutritional measures Psychological support
4
Zhang et al 2014 RCT N = 84 patients (42 control group, 42 treatment group)
Lidocaine
Topical
Treatment
Lidocaine gargle solution Appropriate dietary and nutritional measures
5
Zhang Xiao Qing et al (2016) RCT N=60 (30 control group, 30 treatment group)
Lidocaine
Topical
Treatment
Lidocaine gargle solution Appropriate dietary and nutritional measures
6
Li Liang et al (2015)
RCT N=45 (25 treatment group, 20 control)
MEBO
Topical
Treatment
Multi-agent management using kangfuxing and MEBO
7
Huang Jian et al (2009) RCT N=105 (55 treatment group, 50=control group)
Recombinant human epidermal growth factor
Topical
Treatment and preventive
Multi-agent management using recombinant human epidermal growth factor and lidocaine gargle solution
8
Chen Shao et al (2013) RCT N=61 (31 treatment group, 30 control group)
Compounded preparation (dexamethasone, gentamicin and lidocaine)
Topical
Treatment and preventative
Compounded mouth wash containing normal saline, 2% lidocaine, dexamethasone and gentamicin
9
Qiu Hong et al (2018) RCT N=40 (20 treatment group, 20 control group)
Compounded preparation
Topical
Treatment and preventative
Multi-agent management using qingkou mouth rinse and a compounded paste (tea oil, montmorillonite powder and vitamin C)
10
Liu Qing et al (2012)
RCT N=59 (30 treatment group, 29 control group)
Dexamethasone
Topical
Treatment and preventative
Dexamethasone gargling solution