Literature search
We performed a detailed systematic search through both medical and
nursing databases (PUBMED (MEDLINE), SCOPUS, SCIENCE DIRECT, EBSCO,
CNKI, XUESHU and COCHRANE DATABASE) to identify related clinical trials
in relation to mucosal damaged induced by paraquat between 2000 to
December 2020. Our searches explored the keywords (paraquat, paraquat
induced oral mucositis, paraquat tongue, oral care, mucosal injury). The
population, intervention, comparison, outcome (PICO) model was used to
develop inclusion criteria and search terms per intervention. Population
focused on patients who presented with symptoms of oral mucositis after
paraquat ingestion. Intervention highlighted the different agents and
modes of intervention that were applied in the different trials and a
comparison of the management received by the control group and a lack
thereof. Outcome was based on improved healing/recovery time.