Multi-agent or compounded preparations
Multi-agent formulations contain several ingredients (at least three ingredients). These ingredients may include an antibiotic, a local anesthetic or topical anesthetic and a steroid to reduce inflammation. Most formulations are used every 4-6 hours. Patients are advised to hold the formulation in the mouth for 2-5 minutes, then spit out or swallow, and to abstain from eating or drinking for 30 minutes after use. The three studies that focused on multi-agent preparations and mouthwashes have not only demonstrated their superiority over bland rinses to treat mucositis but also alleviate pain 2122 25