Statins Strain Description Titer Ref.
Simvastatin S. cerevisiae BY4741 Introducing the synthetic gene of monacline J; adding the acyl-donor dimethylbutyryl-S-methyl mercaptopropionate (DMB-SMMP) into the culture medium; In situ chemical lysis of cell wall 55 mg/L (Bond and Tang 2019)
Lovastatin P. pastoris GS115 Introducing lovastatin synthesis gene into P. pastoris GS115; using dihydromonacolin L as a metabolic node, dividing the synthetic pathway into upstream and downstream modules; Co-culture strategy 250.8 mg/L (Liu, Tu et al. 2018)
Overexpressing the statins pump protein TapA (a membrane protein that enables lovastatin to flow out of cells) 419.0±9.5 mg/L (Liu, Bai et al. 2018)
A. terreus ATCC 20542 Inserting the antibiotic marker hygromycin B (hyg) within the gedC gene that encodes emodin anthrone polyketide synthase (PKS), a primary gene responsible for initiating (+)-geodin biosynthesis to get an A. terreus mutant strain (gedCΔ) 113 mg/L (Hasan, Abd Rahim et al. 2019)
A. terreus EM19 Inducing A. terreus GD13 for three cycles 1424 mg/L (Kaur, Kaur et al. 2009)
Fusarium sp. Alaa-20 Enhancing mutagenesis induction and three successive gene recombination of Fusarium sp. Alaa-20 52.1 mg/gds (El-Bondkly, El-Gendy et al. 2021)
Pravastatin Streptomyces sp. Y-110 Adding compactin to the medium intermittently 1000 mg/L (Park, Lee et al. 2003)
P. chrysogenum DS50662 Introducing the compactin pathway into the beta-lactam-negative P. chrysogenum DS50662; A evolved cytochrome P450 (P450 or CYP) were used to catalyze the final compactin hydroxylation step 6 g/L (McLean, Hans et al. 2015)