ORCID
Shuangyan Han: 0000-0002-9869-5829
Data Availability
Statement
Data sharing is not applicable to this article as no new data were
created or analyzed in this study.
Author Contributions
All authors contributed to the background research and writing of the
article, as well as the editing. In addition, all authors have read and
approved the final version of this manuscript.
Conflicts Of Interest
The authors declare that there are no conflicts of interest.
Funding Information
This work was supported by the National Key R&D Program of China
(2021YFC2102700).
Reference
(2012). ”Metabolic Engineering and Synthetic Biology in Strain
Development.” ACS Synthetic Biology 1 (11): 491-492.
A. Massy, Z. and C. Guijarro (2001). ”Statins: effects beyond
cholesterol lowering.” Nephrology Dialysis Transplantation16 (9): 1738-1741.
Abd Rahim, M. H., E. J. Lim, H. Hasan and A. Abbas (2019). ”The
investigation of media components for optimal metabolite production of
Aspergillus terreus ATCC 20542.” Journal of Microbiological
Methods 164 : 105672.
Abe, Y., T. Suzuki, T. Mizuno, C. Ono, K. Iwamoto, M. Hosobuchi and H.
Yoshikawa (2002). ”Effect of increased dosage of the ML-236B (compactin)
biosynthetic gene cluster on ML-236B production in Penicillium
citrinum.” Molecular Genetics and Genomics 268 (1):
130-137.
Abe, Y., T. Suzuki, C. Ono, K. Iwamoto, M. Hosobuchi and H. Yoshikawa
(2002). ”Molecular cloning and characterization of an ML-236B
(compactin) biosynthetic gene cluster in Penicillium citrinum.”Molecular Genetics and Genomics 267 (5): 636-646.
Adhyaru, B. B. and T. A. Jacobson (2018). ”Safety and efficacy of statin
therapy.” Nature Reviews Cardiology 15 (12): 757-769.
Ahmad, A., M. Mujeeb, R. Kapoor and B. P. Panda (2013). ”In situ
bioconversion of compactin to pravastatin by Actinomadura species in
fermentation broth of Penicillium citrinum.” Chemical Papers67 (6): 667-671.
Ahmad, A., B. Panda and M. M. (2010). ”Screening of nutrient parameters
for mevastatin production by Penicillium citrinum MTCC 1256 under
submerged fermentation using the Plackett-Burman design.” 2 (1):
44-46.
Alberts, A. W., J. Chen, G. Kuron, V. Hunt, J. Huff, C. Hoffman, J.
Rothrock, M. Lopez, H. Joshua, E. Harris, A. Patchett, R. Monaghan, S.
Currie, E. Stapley, G. Albers-Schonberg, O. Hensens, J. Hirshfield, K.
Hoogsteen, J. Liesch and J. Springer (1980). ”Mevinolin: a highly potent
competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and
a cholesterol-lowering agent.” 77 (7): 3957-3961.
Ansari, F. J., H. Jalili, M. Bizukojc and A. Amrane (2018).
”Optimization of date syrup as a novel medium for lovastatin production
by Aspergillus terreus ATCC 20542 and analyzing assimilation kinetic of
carbohydrates.” Annals of Microbiology 68 (6): 351-363.
Ansari, S., H. Jalili, M. Bizukojc and A. Amrane (2019). ”Influence of
the construction of porous spargers on lovastatin production by
Aspergillus terreus ATCC 20,542 in a laboratory bubble column.”Bioprocess and Biosystems Engineering 42 (7): 1205-1213.
Askin, D., T. R. Verhoeven, T. M. H. Liu and I. Shinkai (1991).
”Synthesis of synvinolin: extremely high conversion alkylation of an
ester enolate.” The Journal of Organic Chemistry 56 (16):
4929-4932.
Atli, B., M. Yamaç and Z. Yildiz (2013). ”Optimization of Submerged
Fermentation Conditions for Lovastatin Production by the
Culinary-Medicinal Oyster Mushroom, <i>Pleurotus
ostreatus</i> (Higher Basidiomycetes).”15 (5): 487-495.
Atlı, B., M. Yamaç, Z. Yıldız and O. S. Isikhuemnen (2015). ”Enhanced
production of lovastatin by Omphalotus olearius (DC.) Singer in solid
state fermentation.” Revista Iberoamericana de Micología32 (4): 247-251.
Azeem, M., M. Arshad, S. Mahmood, S. Abrar, A. F. Zahoor, S. Javed, B.
Tariq and K. Hayyat (2020). ”Development of One Pot Strategy for Hyper
Production and In Vivo Evaluation of Lovastatin.” 25 (19): 4380.
Baba, S., Y. Abe, T. Suzuki, C. Ono, K. Iwamoto, T. Nihira and M.
Hosobuchi (2009). ”Improvement of compactin (ML-236B) production by
genetic engineering in compactin high-producing Penicillium citrinum.”Applied Microbiology and Biotechnology 83 (4): 697-704.
Bai, C., Y. Liu, X. Chen, Z. Qian, H. Liu, X. Zhou, Y. Zhang and M. Cai
(2020). ”Fungal statin pump protein improves monacolin J efflux and
regulates its production in Komagataella phaffii.” Bioresources
and Bioprocessing 7 (1): 32.
Baños, J. G., A. Tomasini, G. Szakács and J. Barrios-González (2009).
”High lovastatin production by Aspergillus terreus in solid-state
fermentation on polyurethane foam: An artificial inert support.”Journal of Bioscience and Bioengineering 108 (2):
105-110.
Barrios-González, J. and R. U. Miranda (2010). ”Biotechnological
production and applications of statins.” Applied Microbiology and
Biotechnology 85 (4): 869-883.
Binnington, B., L. Nguyen, M. Kamani, D. Hossain, D. L. Marks, M. Budani
and C. A. Lingwood (2015). ”Inhibition of Rab prenylation by statins
induces cellular glycosphingolipid remodeling.” Glycobiology26 (2): 166-180.
Bond, C. M. and Y. Tang (2019). ”Engineering Saccharomyces cerevisiae
for production of simvastatin.” Metabolic Engineering51 : 1-8.
Breedlove, C. and H. Hedrick (1999). ”Reenvisioning Medical Education
for the New MillenniumCall for Papers.” JAMA 282 (22):
2171-2171.
Chakravarti, R. and V. Sahai (2002). ”A chemically-defined medium for
production of compactin by Penicillium citrinum.” Biotechnology
Letters 24 (7): 527-530.
Chakravarti, R. and V. Sahai (2002). ”Optimization of compactin
production in chemically defined production medium by Penicillium
citrinum using statistical methods.” Process Biochemistry38 (4): 481-486.
Chekanov, K., D. Litvinov, T. Fedorenko, O. Chivkunova and E. Lobakova
(2021). ”Combined Production of Astaxanthin and β-Carotene in a New
Strain of the Microalga Bracteacoccus aggregatus BM5/15 (IPPAS C-2045)
Cultivated in Photobioreactor.” 10 (7): 643.
Chioua, M. and J. Marco-Contelles (2021). ”Synthesis of New Statin
Derivatives.” 6 (47): 13633-13635.
Choi, D., K. Cho, W. S. Cha and S. R. Ryu (2004). ”Effect of triton
X-100 on compactin production fromPenicillium citrinum.”Biotechnology and Bioprocess Engineering 9 (3): 171-178.
Cummings, S. R. and D. C. Bauer (2000). ”Do Statins Prevent Both
Cardiovascular Disease and Fracture?” JAMA 283 (24):
3255-3257.
Davies, M. E., D. Tsyplenkov and V. J. J. Martin (2021). ”Engineering
Yeast for De Novo Synthesis of the Insect Repellent Nepetalactone.”ACS Synthetic Biology 10 (11): 2896-2903.
Dzhavakhiya, V. V., T. M. Voinova, E. V. Glagoleva, D. V. Petukhov, A.
I. Ovchinnikov, M. I. Kartashov, B. B. Kuznetsov and K. G. Skryabin
(2015). ”Strain Improvement of Streptomyces xanthochromogenes RIA 1098
for Enhanced Pravastatin Production at High Compactin Concentrations.”Indian Journal of Microbiology 55 (4): 440-446.
El-Bondkly, A. A. M., M. M. A. A. El-Gendy and A. M. A. El-Bondkly
(2021). ”Construction of Efficient Recombinant Strain Through Genome
Shuffling in Marine Endophytic Fusarium sp. ALAA-20 for Improvement
Lovastatin Production Using Agro-Industrial Wastes.” Arabian
Journal for Science and Engineering 46 (1): 175-190.
Endo, A., M. Kuroda and K. Tanzawa (1976). ”Competitive inhibition of
3-hydroxy-3-methylglutaryl coenzyme a reductase by ML-236A and ML-236B
fungal metabolites, having hypocholesterolemic activity.”72 (2): 323-326.
Galanie, S., K. Thodey, I. J. Trenchard, M. Filsinger Interrante and C.
D. Smolke (2015). ”Complete biosynthesis of opioids in yeast.”Science 349 (6252): 1095-1100.
Giugliano, D., M. I. Maiorino, M. Longo and K. Esposito (2019). ”Are
gliflozins the new statins for diabetes?” Diabetes Research and
Clinical Practice 153 : 191-193.
Gonciarz, J. and M. Bizukojc (2014). ”Adding talc microparticles to
Aspergillus terreus ATCC 20542 preculture decreases fungal pellet size
and improves lovastatin production.” 14 (2): 190-200.
Gonciarz, J., A. Kowalska and M. Bizukojc (2016). ”Application of
microparticle-enhanced cultivation to increase the access of oxygen to
Aspergillus terreus ATCC 20542 mycelium and intensify lovastatin
biosynthesis in batch and continuous fed-batch stirred tank
bioreactors.” Biochemical Engineering Journal 109 :
178-188.
Hajjaj, H., P. Niederberger and P. Duboc (2001). ”Lovastatin
Biosynthesis by <i>Aspergillus
terreus</i> in a Chemically Defined Medium.”67 (6): 2596-2602.
Hasan, H., M. H. Abd Rahim, L. Campbell, D. Carter, A. Abbas and A.
Montoya (2019). ”Improved lovastatin production by inhibiting (+)-geodin
biosynthesis in Aspergillus terreus.” N Biotechnol 52 :
19-24.
Healy, A., J. M. Berus, J. L. Christensen, C. Lee, C. Mantsounga, W.
Dong, J. P. Watts, M. Assali, N. Ceneri, R. Nilson, J. Neverson, W.-C.
Wu, G. Choudhary and A. R. Morrison (2020). ”Statins Disrupt Macrophage
Rac1 Regulation Leading to Increased Atherosclerotic Plaque
Calcification.” Arteriosclerosis, Thrombosis, and Vascular
Biology 40 (3): 714-732.
Huang, X., Y. Liang, Y. Yang and X. Lu (2017). ”Single-step production
of the simvastatin precursor monacolin J by engineering of an industrial
strain of Aspergillus terreus.” Metabolic Engineering42 : 109-114.
Huang, X., S. Tang, L. Zheng, Y. Teng, Y. Yang, J. Zhu and X. Lu (2019).
”Construction of an Efficient and Robust Aspergillus terreus Cell
Factory for Monacolin J Production.” ACS Synthetic Biology8 (4): 818-825.
Iewkittayakorn, J., K. Kuechoo, Y. Sukpondma, V. Rukachaisirikul, S.
Phongpaichit and W. Chotigeat (2020). ”Lovastatin Production by
Aspergillus sclerotiorum Using Agricultural Waste.” Food Technol
Biotechnol 58 (2): 230-236.
Itoh, H., A. Miura, M. Matsui, T. Arazoe, K. Nishida, T. Kumagai, M.
Arita, K. Tamano, M. Machida and T. Shibata (2018). ”Knockout of the
SREBP system increases production of the polyketide FR901512 in
filamentous fungal sp. No. 14919 and lovastatin in Aspergillus terreus
ATCC20542.” Applied Microbiology and Biotechnology102 (3): 1393-1405.
Jahnke, W. (2007). ”Perspectives of biomolecular NMR in drug discovery:
the blessing and curse of versatility.” Journal of Biomolecular
NMR 39 (2): 87-90.
Javed, S., A. S. Bukhari, M. Ali and R. Sajjad ur (2016). ”Estimation of
Antifungal Activity of Mevastatin Produced by Aspergillus terreus
GCBL-03 on pretreated substrate in solid state fermentation.”Current Pharmaceutical Biotechnology 17 (3): 291-298.
Jia, Z., X. Zhang, Y. Zhao and X. Cao (2009). ”Effects of divalent metal
cations on lovastatin biosynthesis from Aspergillus terreus in
chemically defined medium.” World Journal of Microbiology and
Biotechnology 25 (7): 1235-1241.
Jia, Z., X. Zhang, Y. Zhao and X. Cao (2010). ”Enhancement of Lovastatin
Production by Supplementing Polyketide Antibiotics to the Submerged
Culture of Aspergillus terreus.” Applied Biochemistry and
Biotechnology 160 (7): 2014-2025.
Kaur, H., A. Kaur, H. Saini and B. Chadha (2009). ”Screening and
selection of lovastatin hyper-producing mutants of Aspergillus terreus
using cyclic mutagenesis %J Acta Microbiologica et Immunologica
Hungarica.” 56 (2): 169-180.
Kaur, H., A. Kaur, H. Saini and B. Chadha (2010). ”Response surface
methodology for lovastatin production by Aspergillus terreus GD13 strain
%J Acta Microbiologica et Immunologica Hungarica.” 57 (4):
377-391.
Kónya, A., A. Jekkel, J. Sütő and J. Salát (1998). ”Optimization of
compactin fermentation.” Journal of Industrial Microbiology and
Biotechnology 20 (3-4): 150-152.
Kumar, S., N. Srivastava, B. S. Gupta, R. C. Kuhad and J. Gomes (2014).
”Lovastatin production by Aspergillus terreus using lignocellulose
biomass in large scale packed bed reactor.” Food and Bioproducts
Processing 92 (4): 416-424.
Lai, L.-S. T., T.-H. Tsai, T. C. Wang and T.-Y. Cheng (2005). ”The
influence of culturing environments on lovastatin production by
Aspergillus terreus in submerged cultures.” Enzyme and Microbial
Technology 36 (5): 737-748.
Liang, B., X. Huang, Y. Teng, Y. Liang, Y. Yang, L. Zheng and X. Lu
(2018). ”Enhanced Single-Step Bioproduction of the Simvastatin Precursor
Monacolin J in an Industrial Strain of Aspergillus terreus by Employing
the Evolved Lovastatin Hydrolase.” 13 (6): 1800094.
Lin, C.-L., Y.-L. Tang and S.-M. Lin (2011). ”Efficient bioconversion of
compactin to pravastatin by the quinoline-degrading microorganism
Pseudonocardia carboxydivorans isolated from petroleum-contaminated
soil.” Bioresource Technology 102 (22): 10187-10193.
Lin, S.-y., K. Baumann, C. Zhou, W. Zhou, A. E. Cuellar and H. Xue
(2021). ”Trends in Use and Expenditures for Brand-name Statins After
Introduction of Generic Statins in the US, 2002-2018.” JAMA
Network Open 4 (11): e2135371-e2135371.
Liu, C.-L., K. Xue, Y. Yang, X. Liu, Y. Li, T. S. Lee, Z. Bai and T. Tan
(2022). ”Metabolic engineering strategies for sesquiterpene production
in microorganism.” Critical Reviews in Biotechnology42 (1): 73-92.
Liu, Y., C. Bai, Q. Xu, J. Yu, X. Zhou, Y. Zhang and M. Cai (2018).
”Improved methanol-derived lovastatin production through enhancement of
the biosynthetic pathway and intracellular lovastatin efflux in
methylotrophic yeast.” Bioresources and Bioprocessing5 (1): 22.
Liu, Y., X. Tu, Q. Xu, C. Bai, C. Kong, Q. Liu, J. Yu, Q. Peng, X. Zhou,
Y. Zhang and M. Cai (2018). ”Engineered monoculture and co-culture of
methylotrophic yeast for de novo production of monacolin J and
lovastatin from methanol.” Metabolic Engineering 45 :
189-199.
Maltsev, Y. I., I. A. Maltseva, S. Y. Maltseva and M. S. Kulikovskiy
(2020). ”Biotechnological Potential of a New Strain of Bracteacoccus
bullatus (Sphaeropleales, Chlorophyta) as a Promising Producer of
Omega-6 Polyunsaturated Fatty Acids.” Russian Journal of Plant
Physiology 67 (1): 185-193.
Manzoni, M. and M. Rollini (2002). ”Biosynthesis and biotechnological
production of statins by filamentous fungi and application of these
cholesterol-lowering drugs.” Applied Microbiology and
Biotechnology 58 (5): 555-564.
McLean, K. J., M. Hans, B. Meijrink, W. B. van Scheppingen, A.
Vollebregt, K. L. Tee, J.-M. van der Laan, D. Leys, A. W. Munro and M.
A. van den Berg (2015). ”Single-step fermentative production of the
cholesterol-lowering drug pravastatin via reprogramming of
<em>Penicillium
chrysogenum</em>.” 112 (9): 2847-2852.
Miranda, R. U., L. E. Gómez-Quiroz, M. Mendoza, A. Pérez-Sánchez, F.
Fierro and J. Barrios-González (2014). ”Reactive oxygen species regulate
lovastatin biosynthesis in Aspergillus terreus during submerged and
solid-state fermentations.” Fungal Biology 118 (12):
979-989.
Nielsen, J. and J. T. Pronk (2012). ”Metabolic engineering, synthetic
biology and systems biology.” FEMS Yeast Research 12 (2):
103-103.
Novo, M., F. Bigey, E. Beyne, V. Galeote, F. Gavory, S. Mallet, B.
Cambon, J.-L. Legras, P. Wincker, S. Casaregola and S. Dequin (2009).
”Eukaryote-to-eukaryote gene transfer events revealed by the genome
sequence of the wine yeast <span class=”named-content
genus-species”>Saccharomyces
cerevisiae</span> EC1118.” 106 (38):
16333-16338.
Oliveira, M. C. L. d., A. J. Paulo, C. d. A. Lima, J. L. de Lima Filho,
C. M. Souza-Motta, E. E. Vidal, T. P. Nascimento, D. d. A. V. Marques
and A. L. F. Porto (2021). ”Lovastatin producing by wild strain of
Aspergillus terreus isolated from Brazil.” Preparative
Biochemistry & Biotechnology 51 (2): 164-172.
Osmak, M. (2012). ”Statins and cancer: Current and future prospects.”Cancer Letters 324 (1): 1-12.
Panda, B. P., S. Javed and M. Ali (2010). ”Optimization of Fermentation
Parameters for Higher Lovastatin Production in Red Mold Rice through
Co-culture of Monascus purpureus and Monascus ruber.” Food and
Bioprocess Technology 3 (3): 373-378.
Pansuriya, R. C. and R. S. Singhal (2010). ”Response surface methodology
for optimization of production of lovastatin by solid state
fermentation.” Braz J Microbiol 41 (1): 164-172.
Park, J.-W., J.-K. Lee, T.-J. Kwon, D.-H. Yi, Y.-J. Kim, S.-H. Moon,
H.-H. Suh, S.-M. Kang and Y.-I. Park (2003). ”Bioconversion of compactin
into pravastatin by Streptomyces sp.” Biotechnology Letters25 (21): 1827-1831.
Pawlak, M. and M. Bizukojc (2013). ”Feeding profile is not the sole
factor influencing lovastatin production by Aspergillus terreus
ATCC20542 in a continuous fed-batch stirred tank bioreactor.”Biochemical Engineering Journal 81 : 80-89.
Pecyna, M. and M. Bizukojc (2011). ”Lovastatin biosynthesis by
Aspergillus terreus with the simultaneous use of lactose and glycerol in
a discontinuous fed-batch culture.” Journal of Biotechnology151 (1): 77-86.
Petek, B., M. Villa-Lopez, R. Loera-Valencia, G. Gerenu, B. Winblad, M.
G. Kramberger, M.-A.-M. Ismail, M. Eriksdotter and S. Garcia-Ptacek
(2018). ”Connecting the brain cholesterol and renin–angiotensin
systems: potential role of statins and RAS-modifying medications in
dementia.” Journal of Internal Medicine 284 (6): 620-642.
Porcel, E. M. R., J. L. C. López, J. A. S. Pérez and Y. Chisti (2008).
”Lovastatin production by Aspergillus terreus in a two-staged feeding
operation.” 83 (9): 1236-1243.
Porcel, E. R., J. L. C. López, M. A. V. Ferrón, J. A. S. Pérez, J. L. G.
Sánchez and Y. Chisti (2006). ”Effects of the sporulation conditions on
the lovastatin production by Aspergillus terreus.” Bioprocess and
Biosystems Engineering 29 (1): 1-5.
Rikitake, Y. and J. K. Liao (2005). ”Rho GTPases, Statins, and Nitric
Oxide.” Circulation Research 97 (12): 1232-1235.
Ro, D.-K., E. M. Paradise, M. Ouellet, K. J. Fisher, K. L. Newman, J. M.
Ndungu, K. A. Ho, R. A. Eachus, T. S. Ham, J. Kirby, M. C. Y. Chang, S.
T. Withers, Y. Shiba, R. Sarpong and J. D. Keasling (2006). ”Production
of the antimalarial drug precursor artemisinic acid in engineered
yeast.” Nature 440 (7086): 940-943.
Rollini, M. and M. Manzoni (2006). ”Influence of medium design on
lovastatin and mevastatin production byAspergillus terreus strains.”Annals of Microbiology 56 (1): 47.
Sayyad, S. A., B. P. Panda, S. Javed and M. Ali (2007). ”Optimization of
nutrient parameters for lovastatin production by Monascus purpureus MTCC
369 under submerged fermentation using response surface methodology.”Applied Microbiology and Biotechnology 73 (5): 1054-1058.
Shaligram, N. S., S. K. Singh, R. S. Singhal, A. Pandey and G. Szakacs
(2008). ”Compactin Production Studies Using Penicillium brevicompactum
Under Solid-State Fermentation Conditions.” Applied Biochemistry
and Biotechnology 159 (2): 505.
Shaligram, N. S., S. K. Singh, R. S. Singhal, G. Szakacs and A. Pandey
(2008). ”Compactin production in solid-state fermentation using
orthogonal array method by P. brevicompactum.” Biochemical
Engineering Journal 41 (3): 295-300.
Srinivasan, N., K. Thangavelu and S. Uthandi (2022). ”Lovastatin
production by an oleaginous fungus, Aspergillus terreus KPR12 using sago
processing wastewater (SWW).” Microbial Cell Factories21 (1): 22.
Sripalakit, P. and A. Saraphanchotiwitthaya (2020). ”Lovastatin
Production from Aspergillus Terreus ATCC 20542 Under Various Vegetable
Oils Used as Sole and Supplementary Carbon Sources.”Pharmaceutical Chemistry Journal 54 (3): 302-309.
Subhagar, S., R. Aravindan and T. Viruthagiri (2009). ”Response surface
optimization of mixed substrate solid state fermentation for the
production of lovastatin by Monascus purpureus.” 9 (4): 303-310.
Suraiya, S., J.-H. Kim, J. Y. Tak, M. P. Siddique, C. J. Young, J. K.
Kim and I.-S. Kong (2018). ”Influences of fermentation parameters on
lovastatin production by Monascus purpureus using Saccharina japonica as
solid fermented substrate.” LWT 92 : 1-9.
Syed, M. B. and M. Rajasimman (2015). ”Fermentative production and
optimization of mevastatin in submerged fermentation using Aspergillus
terreus.” Biotechnology Reports 6 : 124-128.
Syed, M. B., A. Rajendran, S. Seraman and V. Thangavelu (2014).
”Valorization of Agricultural Residues for Compactin Production by
Aspergillus terreus MTCC 279 in Mixed Substrate Solid State
Fermentation.” Waste and Biomass Valorization 5 (4):
715-724.
Tartaggia, S., S. Fogal, R. Motterle, C. Ferrari, M. Pontini, R. Aureli
and O. De Lucchi (2016). ”Chemoenzymatic Synthesis of δ-Keto β-Hydroxy
Esters as Useful Intermediates for Preparing Statins.”2016 (19): 3162-3165.
Valera, H. R., J. Gomes, S. Lakshmi, R. Gururaja, S. Suryanarayan and D.
Kumar (2005). ”Lovastatin production by solid state fermentation using
Aspergillus flavipes.” Enzyme and Microbial Technology37 (5): 521-526.
Vatanparast, M. and Y. Kim (2019). ”Yeast engineering to express sex
pheromone gland genes of the oriental fruit moth, Grapholita molesta.”Journal of Asia-Pacific Entomology 22 (3): 645-654.
Xie, X., K. Watanabe, W. A. Wojcicki, C. C. C. Wang and Y. Tang (2006).
”Biosynthesis of Lovastatin Analogs with a Broadly Specific
Acyltransferase.” Chemistry & Biology 13 (11):
1161-1169.
Zeng, X., J. Zheng, F. Lu, L. Pan and B. Wang (2022). ”Heterologous
Synthesis of Monacolin J by Reconstructing Its Biosynthetic Gene Cluster
in Aspergillus niger.” 8 (4): 407.
Zhou, Z., A. J. Curtis, M. Breslin and M. Nelson (2019). ”Letter by Zhou
et al Regarding Article, “Statin Toxicity: Mechanistic Insights and
Clinical Implications”.” Circulation Research 124 (12):
e120-e120.