2.5 Control dataset
The global comparison of the structure network was performed earlier on a dataset of single chain single domain proteins to determine their structure variability. There, all pairs of available multiple conformers of the same protein are compared to determine the network dissimilarity (NDS) and structure deviation (RMSD) scores. In this work, the data from the previous analysis has been used as a control to understand the significance of the variability obtained upon transient association. The two-sample Kolmogorov-Smirnov test (KS test) is performed to test the significance of the data obtained in the working dataset as compared to the corresponding scores of the control dataset.